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In Situ Hybridization Tissue Test

Nationwide rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated July 2026.

Facilitymedian $95 · 10th–90th $49$4790%20%10th90th$95Professionalmedian $214 · 10th–90th $49$5890%10%10th90th$214$1.0$10.0$100.0$1.0K$10.0K$100.0K

Distribution of negotiated rates across all payers (price axis is log-scale). Facility and professional rates are different services and are charted separately. Need provider-level prices? Contact us.

Insurance Carrier
Aetna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$47.86
Median
$58.88
Typical High
$151.36
Aetna
Setting
Professional
Modifier
Global
Typical Low
$194.98
Median
$295.12
Typical High
$645.65
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$39.81
Median
$58.88
Typical High
$169.82
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$131.83
Median
$251.19
Typical High
$478.63
BCBS
Setting
Professional
Modifier
Global
Typical Low
$154.88
Median
$223.87
Typical High
$776.25
BCBS
Setting
Professional
Modifier
26 · Professional part
Typical Low
$26.92
Median
$56.23
Typical High
$151.36
BCBS
Setting
Professional
Modifier
TC · Technical part
Typical Low
$128.82
Median
$173.78
Typical High
$630.96
Cigna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$36.31
Median
$169.82
Typical High
$288.40
Cigna
Setting
Professional
Modifier
Global
Typical Low
$109.65
Median
$257.04
Typical High
$691.83
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$30.90
Median
$60.26
Typical High
$123.03
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$75.86
Median
$204.17
Typical High
$575.44
United
Setting
Professional
Modifier
Global
Typical Low
$173.78
Median
$363.08
Typical High
$831.76
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$38.02
Median
$69.18
Typical High
$218.78
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$128.82
Median
$295.12
Typical High
$691.83