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In Situ Hybridization Tissue Test

Maryland rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated July 2026.

How much does In Situ Hybridization Tissue Test cost?

$355

Typical negotiated rate. In Maryland, July 2026.

Insurers have agreed to pay about $355 for this service. Most negotiated rates run $288 to $407.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $355 · 10th to 90th $151 to $851
$100$200$500$1Kprofessional $355

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$34.67
Median
$34.67
Typical High
$47.86
Aetna
Setting
Professional
Modifier
Global
Typical Low
$190.55
Median
$354.81
Typical High
$851.14
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$42.66
Median
$51.29
Typical High
$123.03
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$93.33
Median
$309.03
Typical High
$758.58
CareFirst
Setting
Professional
Modifier
Global
Typical Low
$58.88
Median
$354.81
Typical High
$407.38
CareFirst
Setting
Professional
Modifier
26 · Professional part
Typical Low
$50.12
Median
$53.70
Typical High
$64.57
CareFirst
Setting
Professional
Modifier
TC · Technical part
Typical Low
$288.40
Median
$302.00
Typical High
$380.19
Cigna
Setting
Professional
Modifier
Global
Typical Low
$4.47
Median
$234.42
Typical High
$660.69
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$0.71
Median
$36.31
Typical High
$112.20
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$3.80
Median
$190.55
Typical High
$645.65
Kaiser Permanente
Setting
Professional
Modifier
Global
Typical Low
$407.38
Median
$489.78
Typical High
$645.65
Kaiser Permanente
Setting
Professional
Modifier
26 · Professional part
Typical Low
$63.10
Median
$75.86
Typical High
$95.50
Kaiser Permanente
Setting
Professional
Modifier
TC · Technical part
Typical Low
$346.74
Median
$416.87
Typical High
$549.54
United
Setting
Professional
Modifier
Global
Typical Low
$151.36
Median
$354.81
Typical High
$562.34
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$42.66
Median
$64.57
Typical High
$120.23
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$109.65
Median
$302.00
Typical High
$478.63
Wellpoint
Setting
Professional
Modifier
Global
Typical Low
$338.84
Median
$575.44
Typical High
$645.65
Wellpoint
Setting
Professional
Modifier
26 · Professional part
Typical Low
$54.95
Median
$85.11
Typical High
$95.50
Wellpoint
Setting
Professional
Modifier
TC · Technical part
Typical Low
$281.84
Median
$489.78
Typical High
$562.34

Where Maryland sits

The same service costs 4.7 times more in Minnesota than in Rhode Island. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Maryland· 18th of 51

$355

MN $794RI $170

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.