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In Situ Hybridization Tissue Test

Maryland rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated October 2026.

How much does In Situ Hybridization Tissue Test cost?

$355

Typical negotiated rate. In Maryland, October 2026.

Insurers have agreed to pay about $355 for this service. Most negotiated rates run $302 to $398.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Facilitymedian $468 · 10th to 90th $316 to $631Professionalmedian $355 · 10th to 90th $209 to $550
$200$500$1Kfacility $468professional $355

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$316.23
Median
$467.74
Typical High
$630.96
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$213.80
Median
$316.23
Typical High
$616.60
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$33.88
Median
$51.29
Typical High
$93.33
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$181.97
Median
$269.15
Typical High
$524.81
CareFirst
Setting
Professional
Modifier
None (both parts)
Typical Low
$302.00
Median
$354.81
Typical High
$398.11
CareFirst
Setting
Professional
Modifier
26 · Professional part
Typical Low
$52.48
Median
$53.70
Typical High
$58.88
CareFirst
Setting
Professional
Modifier
TC · Technical part
Typical Low
$288.40
Median
$338.84
Typical High
$346.74
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$165.96
Median
$213.80
Typical High
$758.58
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$28.18
Median
$34.67
Typical High
$114.82
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$141.25
Median
$177.83
Typical High
$645.65
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$407.38
Median
$512.86
Typical High
$645.65
Kaiser Permanente
Setting
Professional
Modifier
26 · Professional part
Typical Low
$63.10
Median
$77.62
Typical High
$93.33
Kaiser Permanente
Setting
Professional
Modifier
TC · Technical part
Typical Low
$346.74
Median
$436.52
Typical High
$549.54
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$151.36
Median
$323.59
Typical High
$831.76
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$41.69
Median
$53.70
Typical High
$131.83
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$109.65
Median
$275.42
Typical High
$707.95
Wellpoint
Setting
Professional
Modifier
None (both parts)
Typical Low
$338.84
Median
$338.84
Typical High
$645.65
Wellpoint
Setting
Professional
Modifier
26 · Professional part
Typical Low
$54.95
Median
$54.95
Typical High
$95.50
Wellpoint
Setting
Professional
Modifier
TC · Technical part
Typical Low
$281.84
Median
$281.84
Typical High
$549.54
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$151.36
Median
$158.49
Typical High
$177.83
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$60.26
Median
$64.57
Typical High
$72.44

Where Maryland sits

The same service costs 9.1 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Maryland· 28th of 51

$355

AK $891AL $97.72

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.