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In Situ Hybridization Tissue Test

Michigan rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated July 2026.

How much does In Situ Hybridization Tissue Test cost?

$275

Typical negotiated rate. In Michigan, July 2026.

Insurers have agreed to pay about $275 for this service. Most negotiated rates run $245 to $347.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $275 · 10th to 90th $191 to $479
$100$200$500$1Kprofessional $275

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
Global
Typical Low
$190.55
Median
$275.42
Typical High
$467.74
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$39.81
Median
$60.26
Typical High
$147.91
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$131.83
Median
$245.47
Typical High
$389.05
Ambetter
Setting
Professional
Modifier
26 · Professional part
Typical Low
$60.26
Median
$60.26
Typical High
$81.28
BCBS
Setting
Professional
Modifier
Global
Typical Low
$125.89
Median
$588.84
Typical High
$588.84
BCBS
Setting
Professional
Modifier
26 · Professional part
Typical Low
$100.00
Median
$100.00
Typical High
$100.00
BCBS
Setting
Professional
Modifier
TC · Technical part
Typical Low
$398.11
Median
$398.11
Typical High
$398.11
CareSource
Setting
Professional
Modifier
Global
Typical Low
$64.57
Median
$346.74
Typical High
$467.74
Cigna
Setting
Professional
Modifier
Global
Typical Low
$107.15
Median
$204.17
Typical High
$660.69
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$28.18
Median
$37.15
Typical High
$147.91
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$72.44
Median
$162.18
Typical High
$446.68
Health Alliance Plan
Setting
Professional
Modifier
Global
Typical Low
$194.98
Median
$288.40
Typical High
$724.44
Health Alliance Plan
Setting
Professional
Modifier
26 · Professional part
Typical Low
$47.86
Median
$63.10
Typical High
$112.20
Health Alliance Plan
Setting
Professional
Modifier
TC · Technical part
Typical Low
$109.65
Median
$234.42
Typical High
$660.69
Priority Health
Setting
Professional
Modifier
Global
Typical Low
$407.38
Median
$478.63
Typical High
$524.81
Priority Health
Setting
Professional
Modifier
26 · Professional part
Typical Low
$81.28
Median
$147.91
Typical High
$147.91
Priority Health
Setting
Professional
Modifier
TC · Technical part
Typical Low
$331.13
Median
$331.13
Typical High
$446.68
United
Setting
Professional
Modifier
Global
Typical Low
$134.90
Median
$245.47
Typical High
$575.44
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$40.74
Median
$69.18
Typical High
$257.04
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$93.33
Median
$186.21
Typical High
$478.63

Where Michigan sits

The same service costs 4.7 times more in Minnesota than in Rhode Island. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Michigan· 42nd of 51

$275

MN $794RI $170

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.