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In Situ Hybridization Tissue Test

Michigan rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated October 2026.

How much does In Situ Hybridization Tissue Test cost?

$479

Typical negotiated rate. In Michigan, October 2026.

Insurers have agreed to pay about $479 for this service. The price depends on where it is billed: about $468 from a physician practice, and about $501 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$468$257 to $589
FacilityA hospital or hospital-owned outpatient department$501$398 to $646

How much rates vary

Facilitymedian $501 · 10th to 90th $251 to $912Professionalmedian $468 · 10th to 90th $195 to $631
$10$20$50$100$200$500$1Kfacility $501professional $468

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$331.13
Median
$338.84
Typical High
$478.63
Aetna
Setting
Facility
Modifier
TC · Technical part
Typical Low
$281.84
Median
$295.12
Typical High
$602.56
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$288.40
Median
$380.19
Typical High
$436.52
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$52.48
Median
$61.66
Typical High
$74.13
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$245.47
Median
$316.23
Typical High
$316.23
Ambetter
Setting
Professional
Modifier
26 · Professional part
Typical Low
$60.26
Median
$60.26
Typical High
$60.26
BCBS Michigan
Setting
Facility
Modifier
None
Typical Low
$398.11
Median
$562.34
Typical High
$1,000.00
BCBS Michigan
Setting
Professional
Modifier
None (both parts)
Typical Low
$501.19
Median
$588.84
Typical High
$630.96
BCBS Michigan
Setting
Professional
Modifier
26 · Professional part
Typical Low
$100.00
Median
$100.00
Typical High
$100.00
BCBS Michigan
Setting
Professional
Modifier
TC · Technical part
Typical Low
$537.03
Median
$537.03
Typical High
$537.03
CareSource
Setting
Facility
Modifier
None
Typical Low
$389.05
Median
$389.05
Typical High
$389.05
CareSource
Setting
Professional
Modifier
None (both parts)
Typical Low
$58.88
Median
$346.74
Typical High
$467.74
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$100.00
Median
$190.55
Typical High
$524.81
Health Alliance Plan
Setting
Facility
Modifier
None
Typical Low
$251.19
Median
$489.78
Typical High
$676.08
Health Alliance Plan
Setting
Facility
Modifier
TC · Technical part
Typical Low
$295.12
Median
$323.59
Typical High
$602.56
Health Alliance Plan
Setting
Professional
Modifier
None (both parts)
Typical Low
$194.98
Median
$257.04
Typical High
$467.74
Health Alliance Plan
Setting
Professional
Modifier
26 · Professional part
Typical Low
$48.98
Median
$64.57
Typical High
$77.62
Health Alliance Plan
Setting
Professional
Modifier
TC · Technical part
Typical Low
$109.65
Median
$165.96
Typical High
$389.05
Priority Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$100.00
Median
$190.55
Typical High
$524.81
United
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$229.09
Typical High
$478.63
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$134.90
Median
$245.47
Typical High
$630.96
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$40.74
Median
$67.61
Typical High
$107.15
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$93.33
Median
$208.93
Typical High
$524.81
8 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$144.54
Median
$165.96
Typical High
$302.00
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$58.88
Median
$66.07
Typical High
$123.03
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$165.96
Median
$186.21
Typical High
$186.21
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$66.07
Median
$75.86
Typical High
$75.86
Health Alliance Plan
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$144.54
Median
$173.78
Typical High
$302.00
Health Alliance Plan
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$58.88
Median
$70.79
Typical High
$123.03
Health Alliance Plan
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$173.78
Median
$234.42
Typical High
$234.42
Health Alliance Plan
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$70.79
Median
$93.33
Typical High
$93.33

Where Michigan sits

The same service costs 9.1 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Michigan· 13th of 51

$479

AK $891AL $97.72

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.