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In Situ Hybridization Tissue Test

Colorado rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated July 2026.

How much does In Situ Hybridization Tissue Test cost?

$302

Typical negotiated rate. In Colorado, July 2026.

Insurers have agreed to pay about $302 for this service. Most negotiated rates run $245 to $417.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $302 · 10th to 90th $229 to $661
$100.0$200.0$500.0$1.0Kprofessional $302

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
Global
Typical Low
$245.47
Median
$302.00
Typical High
$467.74
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$39.81
Median
$46.77
Typical High
$66.07
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$204.17
Median
$251.19
Typical High
$407.38
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$416.87
Median
$416.87
Typical High
$724.44
Anthem BCBS
Setting
Professional
Modifier
26 · Professional part
Typical Low
$63.10
Median
$63.10
Typical High
$109.65
Anthem BCBS
Setting
Professional
Modifier
TC · Technical part
Typical Low
$354.81
Median
$354.81
Typical High
$602.56
Cigna
Setting
Professional
Modifier
Global
Typical Low
$95.50
Median
$208.93
Typical High
$660.69
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$29.51
Median
$39.81
Typical High
$102.33
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$66.07
Median
$165.96
Typical High
$549.54
Kaiser Permanente
Setting
Professional
Modifier
Global
Typical Low
$562.34
Median
$562.34
Typical High
$562.34
Kaiser Permanente
Setting
Professional
Modifier
26 · Professional part
Typical Low
$87.10
Median
$87.10
Typical High
$87.10
Kaiser Permanente
Setting
Professional
Modifier
TC · Technical part
Typical Low
$478.63
Median
$478.63
Typical High
$478.63
Select Health
Setting
Professional
Modifier
Global
Typical Low
$346.74
Median
$501.19
Typical High
$977.24
Select Health
Setting
Professional
Modifier
26 · Professional part
Typical Low
$58.88
Median
$77.62
Typical High
$154.88
Select Health
Setting
Professional
Modifier
TC · Technical part
Typical Low
$288.40
Median
$426.58
Typical High
$831.76
United
Setting
Professional
Modifier
Global
Typical Low
$134.90
Median
$245.47
Typical High
$812.83
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$37.15
Median
$67.61
Typical High
$151.36
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$93.33
Median
$208.93
Typical High
$676.08

Where Colorado sits

The same service costs 4.7 times more in Minnesota than in Rhode Island. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Colorado $302 · 26th of 51
MN $794RI $170

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.