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In Situ Hybridization Tissue Test

Colorado rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated October 2026.

How much does In Situ Hybridization Tissue Test cost?

$427

Typical negotiated rate. In Colorado, October 2026.

Insurers have agreed to pay about $427 for this service. The price depends on where it is billed: about $501 from a physician practice, and about $407 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$501$302 to $813
FacilityA hospital or hospital-owned outpatient department$407$339 to $676

How much rates vary

Facilitymedian $407 · 10th to 90th $209 to $741Professionalmedian $501 · 10th to 90th $178 to $1,318
$100$200$500$1Kfacility $407professional $501

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$302.00
Median
$380.19
Typical High
$676.08
Aetna
Setting
Facility
Modifier
TC · Technical part
Typical Low
$251.19
Median
$575.44
Typical High
$1,174.90
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$229.09
Median
$302.00
Typical High
$467.74
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$39.81
Median
$46.77
Typical High
$66.07
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$169.82
Median
$251.19
Typical High
$407.38
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$338.84
Median
$398.11
Typical High
$707.95
Anthem BCBS
Setting
Professional
Modifier
None (both parts)
Typical Low
$416.87
Median
$812.83
Typical High
$1,412.54
Anthem BCBS
Setting
Professional
Modifier
26 · Professional part
Typical Low
$63.10
Median
$123.03
Typical High
$218.78
Anthem BCBS
Setting
Professional
Modifier
TC · Technical part
Typical Low
$354.81
Median
$691.83
Typical High
$1,202.26
Cigna
Setting
Facility
Modifier
None
Typical Low
$186.21
Median
$407.38
Typical High
$1,000.00
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$95.50
Median
$194.98
Typical High
$660.69
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$29.51
Median
$32.36
Typical High
$120.23
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$66.07
Median
$158.49
Typical High
$549.54
Denver HMP
Setting
Facility
Modifier
None
Typical Low
$302.00
Median
$346.74
Typical High
$549.54
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$489.78
Median
$575.44
Typical High
$1,621.81
Kaiser Permanente
Setting
Professional
Modifier
26 · Professional part
Typical Low
$74.13
Median
$89.13
Typical High
$245.47
Kaiser Permanente
Setting
Professional
Modifier
TC · Technical part
Typical Low
$416.87
Median
$489.78
Typical High
$1,380.38
Select Health
Setting
Facility
Modifier
None
Typical Low
$407.38
Median
$758.58
Typical High
$851.14
Select Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$331.13
Median
$354.81
Typical High
$977.24
United
Setting
Facility
Modifier
None
Typical Low
$741.31
Median
$776.25
Typical High
$891.25
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$128.82
Median
$245.47
Typical High
$831.76
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$37.15
Median
$41.69
Typical High
$134.90
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$89.13
Median
$208.93
Typical High
$691.83

Where Colorado sits

The same service costs 9.1 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 19th of 51

$427

AK $891AL $97.72

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.