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In Situ Hybridization Tissue Test

Arizona rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated October 2026.

How much does In Situ Hybridization Tissue Test cost?

$339

Typical negotiated rate. In Arizona, October 2026.

Insurers have agreed to pay about $339 for this service. The price depends on where it is billed: about $263 from a physician practice, and about $501 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$263$245 to $468
FacilityA hospital or hospital-owned outpatient department$501$269 to $676

How much rates vary

Facilitymedian $501 · 10th to 90th $123 to $759Professionalmedian $263 · 10th to 90th $191 to $2,570
$100$200$500$1K$2Kfacility $501professional $263

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$575.44
Median
$575.44
Typical High
$758.58
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$245.47
Median
$245.47
Typical High
$380.19
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$39.81
Median
$39.81
Typical High
$74.13
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$199.53
Median
$204.17
Typical High
$323.59
Ambetter
Setting
Professional
Modifier
26 · Professional part
Typical Low
$72.44
Median
$72.44
Typical High
$72.44
BCBS Arizona
Setting
Facility
Modifier
None
Typical Low
$112.20
Median
$478.63
Typical High
$724.44
BCBS Arizona
Setting
Professional
Modifier
None (both parts)
Typical Low
$257.04
Median
$269.15
Typical High
$407.38
BCBS Arizona
Setting
Professional
Modifier
26 · Professional part
Typical Low
$41.69
Median
$43.65
Typical High
$64.57
BCBS Arizona
Setting
Professional
Modifier
TC · Technical part
Typical Low
$218.78
Median
$223.87
Typical High
$338.84
Cigna
Setting
Facility
Modifier
None
Typical Low
$144.54
Median
$616.60
Typical High
$933.25
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$123.03
Median
$223.87
Typical High
$501.19
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$30.20
Median
$63.10
Typical High
$93.33
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$85.11
Median
$169.82
Typical High
$478.63
Medica
Setting
Facility
Modifier
None
Typical Low
$245.47
Median
$295.12
Typical High
$758.58
Medica
Setting
Professional
Modifier
None (both parts)
Typical Low
$134.90
Median
$537.03
Typical High
$2,570.40
Medica
Setting
Professional
Modifier
26 · Professional part
Typical Low
$39.81
Median
$91.20
Typical High
$398.11
Medica
Setting
Professional
Modifier
TC · Technical part
Typical Low
$93.33
Median
$446.68
Typical High
$2,187.76
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$128.82
Median
$245.47
Typical High
$524.81
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$37.15
Median
$41.69
Typical High
$87.10
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$89.13
Median
$208.93
Typical High
$446.68
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$123.03
Median
$123.03
Typical High
$141.25
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$48.98
Median
$48.98
Typical High
$56.23

Where Arizona sits

The same service costs 9.1 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Arizona· 31st of 51

$339

AK $891AL $97.72

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.