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In Situ Hybridization Tissue Test

Florida rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated October 2026.

How much does In Situ Hybridization Tissue Test cost?

$288

Typical negotiated rate. In Florida, October 2026.

Insurers have agreed to pay about $288 for this service. The price depends on where it is billed: about $282 from a physician practice, and about $339 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$282$224 to $407
FacilityA hospital or hospital-owned outpatient department$339$214 to $562

How much rates vary

Facilitymedian $339 · 10th to 90th $129 to $1,288Professionalmedian $282 · 10th to 90th $123 to $525
$50$100$200$500$1K$2Kfacility $339professional $282

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$134.90
Median
$251.19
Typical High
$489.78
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$134.90
Median
$257.04
Typical High
$426.58
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$40.74
Median
$46.77
Typical High
$77.62
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$93.33
Median
$208.93
Typical High
$354.81
Ambetter
Setting
Professional
Modifier
26 · Professional part
Typical Low
$30.20
Median
$30.20
Typical High
$38.02
AvMed
Setting
Facility
Modifier
None
Typical Low
$309.03
Median
$407.38
Typical High
$758.58
AvMed
Setting
Professional
Modifier
None (both parts)
Typical Low
$245.47
Median
$331.13
Typical High
$407.38
Cigna
Setting
Facility
Modifier
None
Typical Low
$97.72
Median
$234.42
Typical High
$1,288.25
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$107.15
Median
$213.80
Typical High
$501.19
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$30.90
Median
$44.67
Typical High
$102.33
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$74.13
Median
$169.82
Typical High
$467.74
Florida Blue
Setting
Professional
Modifier
None (both parts)
Typical Low
$154.88
Median
$239.88
Typical High
$501.19
Molina
Setting
Professional
Modifier
None (both parts)
Typical Low
$42.66
Median
$354.81
Typical High
$512.86
United
Setting
Facility
Modifier
None
Typical Low
$199.53
Median
$213.80
Typical High
$213.80
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$128.82
Median
$245.47
Typical High
$831.76
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$30.90
Median
$41.69
Typical High
$151.36
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$89.13
Median
$204.17
Typical High
$602.56
Wellpoint
Setting
Professional
Modifier
None (both parts)
Typical Low
$245.47
Median
$245.47
Typical High
$371.54
Wellpoint
Setting
Professional
Modifier
26 · Professional part
Typical Low
$38.90
Median
$38.90
Typical High
$60.26
Wellpoint
Setting
Professional
Modifier
TC · Technical part
Typical Low
$204.17
Median
$204.17
Typical High
$309.03
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$67.61
Median
$125.89
Typical High
$151.36
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$26.92
Median
$50.12
Typical High
$60.26

Where Florida sits

The same service costs 9.1 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Florida· 43rd of 51

$288

AK $891AL $97.72

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.