go back

In Situ Hybridization Tissue Test

Florida rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated July 2026.

How much does In Situ Hybridization Tissue Test cost?

$282

Typical negotiated rate. In Florida, July 2026.

Insurers have agreed to pay about $282 for this service. Most negotiated rates run $251 to $380.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $282 · 10th to 90th $155 to $1,072
$5.0$20.0$100.0$500.0$2.0Kprofessional $282

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$169.82
Median
$169.82
Typical High
$169.82
Aetna
Setting
Professional
Modifier
Global
Typical Low
$186.21
Median
$281.84
Typical High
$1,148.15
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$40.74
Median
$54.95
Typical High
$288.40
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$93.33
Median
$234.42
Typical High
$323.59
Ambetter
Setting
Professional
Modifier
26 · Professional part
Typical Low
$12.88
Median
$30.20
Typical High
$104.71
AvMed
Setting
Professional
Modifier
Global
Typical Low
$263.03
Median
$338.84
Typical High
$407.38
Cigna
Setting
Professional
Modifier
Global
Typical Low
$109.65
Median
$229.09
Typical High
$575.44
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$30.90
Median
$52.48
Typical High
$102.33
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$75.86
Median
$177.83
Typical High
$478.63
Florida Blue
Setting
Professional
Modifier
Global
Typical Low
$154.88
Median
$239.88
Typical High
$501.19
Florida Blue
Setting
Professional
Modifier
26 · Professional part
Typical Low
$46.77
Median
$69.18
Typical High
$112.20
Florida Blue
Setting
Professional
Modifier
TC · Technical part
Typical Low
$107.15
Median
$162.18
Typical High
$426.58
Molina
Setting
Professional
Modifier
Global
Typical Low
$32.36
Median
$33.11
Typical High
$371.54
United
Setting
Professional
Modifier
Global
Typical Low
$128.82
Median
$245.47
Typical High
$831.76
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$30.90
Median
$42.66
Typical High
$169.82
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$89.13
Median
$199.53
Typical High
$602.56
Wellpoint
Setting
Professional
Modifier
Global
Typical Low
$100.00
Median
$218.78
Typical High
$218.78
Wellpoint
Setting
Professional
Modifier
26 · Professional part
Typical Low
$15.85
Median
$35.48
Typical High
$35.48
Wellpoint
Setting
Professional
Modifier
TC · Technical part
Typical Low
$83.18
Median
$186.21
Typical High
$186.21

Where Florida sits

The same service costs 4.7 times more in Minnesota than in Rhode Island. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Florida $282 · 40th of 51
MN $794RI $170

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.