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In Situ Hybridization Tissue Test

Maine rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated July 2026.

How much does In Situ Hybridization Tissue Test cost?

$550

Typical negotiated rate. In Maine, July 2026.

Insurers have agreed to pay about $550 for this service. Most negotiated rates run $331 to $724.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $550 · 10th to 90th $331 to $1,072
$5.0$20.0$100.0$500.0professional $550

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
Global
Typical Low
$331.13
Median
$331.13
Typical High
$537.03
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$54.95
Median
$54.95
Typical High
$83.18
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$281.84
Median
$281.84
Typical High
$436.52
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$151.36
Median
$588.84
Typical High
$758.58
Anthem BCBS
Setting
Professional
Modifier
26 · Professional part
Typical Low
$23.99
Median
$91.20
Typical High
$117.49
Anthem BCBS
Setting
Professional
Modifier
TC · Technical part
Typical Low
$125.89
Median
$467.74
Typical High
$630.96
Cigna
Setting
Professional
Modifier
Global
Typical Low
$223.87
Median
$309.03
Typical High
$501.19
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$0.66
Median
$60.26
Typical High
$112.20
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$3.80
Median
$275.42
Typical High
$416.87
Harvard Pilgrim
Setting
Professional
Modifier
Global
Typical Low
$478.63
Median
$588.84
Typical High
$1,096.48
Harvard Pilgrim
Setting
Professional
Modifier
26 · Professional part
Typical Low
$75.86
Median
$93.33
Typical High
$173.78
Harvard Pilgrim
Setting
Professional
Modifier
TC · Technical part
Typical Low
$398.11
Median
$489.78
Typical High
$912.01
Martin's Point
Setting
Professional
Modifier
Global
Typical Low
$331.13
Median
$562.34
Typical High
$933.25
Martin's Point
Setting
Professional
Modifier
26 · Professional part
Typical Low
$54.95
Median
$87.10
Typical High
$158.49
Martin's Point
Setting
Professional
Modifier
TC · Technical part
Typical Low
$281.84
Median
$436.52
Typical High
$776.25
United
Setting
Professional
Modifier
Global
Typical Low
$346.74
Median
$575.44
Typical High
$1,096.48
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$53.70
Median
$93.33
Typical High
$173.78
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$295.12
Median
$467.74
Typical High
$912.01

Where Maine sits

The same service costs 4.7 times more in Minnesota than in Rhode Island. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Maine $550 · 7th of 51
MN $794RI $170

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.