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In Situ Hybridization Tissue Test

Maine rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated October 2026.

How much does In Situ Hybridization Tissue Test cost?

$380

Typical negotiated rate. In Maine, October 2026.

Insurers have agreed to pay about $380 for this service. The price depends on where it is billed: about $389 from a physician practice, and about $331 from a hospital or other facility.

Few insurers publish rates for this combination, so treat this figure as a rough guide.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$389$331 to $603
FacilityA hospital or hospital-owned outpatient department$331$331 to $501

How much rates vary

Facilitymedian $331 · 10th to 90th $331 to $54,954Professionalmedian $389 · 10th to 90th $166 to $933
$200$1K$5K$20Kfacility $331professional $389

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$331.13
Median
$331.13
Typical High
$331.13
Aetna
Setting
Professional
Modifier
None
Typical Low
$257.04
Median
$331.13
Typical High
$870.96
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$151.36
Median
$575.44
Typical High
$1,258.93
Cigna
Setting
Facility
Modifier
None
Typical Low
$501.19
Median
$501.19
Typical High
$724.44
Cigna
Setting
Professional
Modifier
None
Typical Low
$257.04
Median
$331.13
Typical High
$524.81
Harvard Pilgrim
Setting
Professional
Modifier
None
Typical Low
$346.74
Median
$549.54
Typical High
$741.31
Martin's Point
Setting
Facility
Modifier
None
Typical Low
$54,954.09
Median
$54,954.09
Typical High
$54,954.09
Martin's Point
Setting
Professional
Modifier
None
Typical Low
$331.13
Median
$331.13
Typical High
$870.96
United
Setting
Professional
Modifier
None
Typical Low
$239.88
Median
$416.87
Typical High
$851.14

Where Maine sits

The same service costs 9.1 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Maine· 24th of 51

$380

AK $891AL $97.72

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.