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In Situ Hybridization Tissue Test

Missouri rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated July 2026.

How much does In Situ Hybridization Tissue Test cost?

$331

Typical negotiated rate. In Missouri, July 2026.

Insurers have agreed to pay about $331 for this service. Most negotiated rates run $234 to $490.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $331 · 10th to 90th $178 to $661
$10.0$50.0$200.0$1.0Kprofessional $331

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
Global
Typical Low
$223.87
Median
$331.13
Typical High
$489.78
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$46.77
Median
$60.26
Typical High
$151.36
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$186.21
Median
$281.84
Typical High
$549.54
Ambetter
Setting
Professional
Modifier
26 · Professional part
Typical Low
$29.51
Median
$30.20
Typical High
$154.88
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$85.11
Median
$239.88
Typical High
$630.96
Anthem BCBS
Setting
Professional
Modifier
26 · Professional part
Typical Low
$26.30
Median
$60.26
Typical High
$125.89
Anthem BCBS
Setting
Professional
Modifier
TC · Technical part
Typical Low
$58.88
Median
$158.49
Typical High
$524.81
BCBS
Setting
Professional
Modifier
Global
Typical Low
$239.88
Median
$346.74
Typical High
$616.60
BCBS
Setting
Professional
Modifier
26 · Professional part
Typical Low
$58.88
Median
$75.86
Typical High
$109.65
BCBS
Setting
Professional
Modifier
TC · Technical part
Typical Low
$165.96
Median
$295.12
Typical High
$512.86
Cigna
Setting
Professional
Modifier
Global
Typical Low
$102.33
Median
$199.53
Typical High
$575.44
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$30.20
Median
$34.67
Typical High
$169.82
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$70.79
Median
$169.82
Typical High
$426.58
Medica
Setting
Facility
Modifier
26 · Professional part
Typical Low
$281.84
Median
$281.84
Typical High
$281.84
Medica
Setting
Professional
Modifier
Global
Typical Low
$218.78
Median
$398.11
Typical High
$2,570.40
Medica
Setting
Professional
Modifier
26 · Professional part
Typical Low
$40.74
Median
$72.44
Typical High
$398.11
Medica
Setting
Professional
Modifier
TC · Technical part
Typical Low
$151.36
Median
$331.13
Typical High
$2,187.76
United
Setting
Professional
Modifier
Global
Typical Low
$218.78
Median
$398.11
Typical High
$831.76
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$39.81
Median
$67.61
Typical High
$134.90
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$173.78
Median
$331.13
Typical High
$691.83

Where Missouri sits

The same service costs 4.7 times more in Minnesota than in Rhode Island. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Missouri $331 · 21st of 51
MN $794RI $170

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.