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In Situ Hybridization Tissue Test

South Dakota rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated July 2026.

How much does In Situ Hybridization Tissue Test cost?

$646

Typical negotiated rate. In South Dakota, July 2026.

Insurers have agreed to pay about $646 for this service. Most negotiated rates run $302 to $759.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $646 · 10th to 90th $302 to $813
$500.0$1.0K$2.0Kprofessional $646

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
Global
Typical Low
$302.00
Median
$302.00
Typical High
$302.00
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$48.98
Median
$169.82
Typical High
$169.82
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$251.19
Median
$933.25
Typical High
$933.25
Avera
Setting
Professional
Modifier
Global
Typical Low
$416.87
Median
$707.95
Typical High
$724.44
Cigna
Setting
Professional
Modifier
Global
Typical Low
$512.86
Median
$676.08
Typical High
$1,071.52
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$81.28
Median
$112.20
Typical High
$169.82
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$436.52
Median
$562.34
Typical High
$891.25
Medica
Setting
Professional
Modifier
Global
Typical Low
$245.47
Median
$660.69
Typical High
$2,570.40
Medica
Setting
Professional
Modifier
26 · Professional part
Typical Low
$39.81
Median
$120.23
Typical High
$398.11
Medica
Setting
Professional
Modifier
TC · Technical part
Typical Low
$204.17
Median
$616.60
Typical High
$2,187.76
Midlands
Setting
Professional
Modifier
Global
Typical Low
$660.69
Median
$660.69
Typical High
$676.08
Midlands
Setting
Professional
Modifier
26 · Professional part
Typical Low
$109.65
Median
$120.23
Typical High
$120.23
Midlands
Setting
Professional
Modifier
TC · Technical part
Typical Low
$549.54
Median
$549.54
Typical High
$562.34
Sanford Health Plan
Setting
Professional
Modifier
Global
Typical Low
$389.05
Median
$691.83
Typical High
$758.58
Sanford Health Plan
Setting
Professional
Modifier
26 · Professional part
Typical Low
$91.20
Median
$112.20
Typical High
$120.23
Sanford Health Plan
Setting
Professional
Modifier
TC · Technical part
Typical Low
$295.12
Median
$575.44
Typical High
$630.96
United
Setting
Professional
Modifier
Global
Typical Low
$234.42
Median
$245.47
Typical High
$870.96
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$37.15
Median
$39.81
Typical High
$138.04
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$199.53
Median
$204.17
Typical High
$724.44
Wellmark
Setting
Professional
Modifier
Global
Typical Low
$676.08
Median
$812.83
Typical High
$870.96
Wellmark
Setting
Professional
Modifier
26 · Professional part
Typical Low
$107.15
Median
$131.83
Typical High
$138.04
Wellmark
Setting
Professional
Modifier
TC · Technical part
Typical Low
$575.44
Median
$676.08
Typical High
$724.44

Where South Dakota sits

The same service costs 4.7 times more in Minnesota than in Rhode Island. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

South Dakota $646 · 4th of 51
MN $794RI $170

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.