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In Situ Hybridization Tissue Test

Minnesota rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated July 2026.

How much does In Situ Hybridization Tissue Test cost?

$794

Typical negotiated rate. In Minnesota, July 2026.

Insurers have agreed to pay about $794 for this service. Most negotiated rates run $513 to $1,148.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $794 · 10th to 90th $288 to $1,549
$200.0$500.0$1.0K$2.0Kprofessional $794

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$58.88
Median
$58.88
Typical High
$58.88
Aetna
Setting
Professional
Modifier
Global
Typical Low
$269.15
Median
$380.19
Typical High
$1,621.81
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$46.77
Median
$67.61
Typical High
$323.59
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$234.42
Median
$323.59
Typical High
$933.25
BCBS
Setting
Professional
Modifier
Global
Typical Low
$630.96
Median
$977.24
Typical High
$1,412.54
BCBS
Setting
Professional
Modifier
26 · Professional part
Typical Low
$100.00
Median
$154.88
Typical High
$229.09
BCBS
Setting
Professional
Modifier
TC · Technical part
Typical Low
$524.81
Median
$870.96
Typical High
$1,202.26
Cigna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$102.33
Median
$524.81
Typical High
$630.96
Cigna
Setting
Professional
Modifier
Global
Typical Low
$524.81
Median
$660.69
Typical High
$831.76
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$83.18
Median
$102.33
Typical High
$131.83
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$436.52
Median
$549.54
Typical High
$707.95
Health Partners
Setting
Facility
Modifier
26 · Professional part
Typical Low
$81.28
Median
$489.78
Typical High
$489.78
Health Partners
Setting
Professional
Modifier
Global
Typical Low
$512.86
Median
$512.86
Typical High
$758.58
Health Partners
Setting
Professional
Modifier
26 · Professional part
Typical Low
$81.28
Median
$81.28
Typical High
$181.97
Health Partners
Setting
Professional
Modifier
TC · Technical part
Typical Low
$380.19
Median
$436.52
Typical High
$645.65
Medica
Setting
Facility
Modifier
26 · Professional part
Typical Low
$281.84
Median
$281.84
Typical High
$281.84
Medica
Setting
Professional
Modifier
Global
Typical Low
$245.47
Median
$794.33
Typical High
$1,659.59
Medica
Setting
Professional
Modifier
26 · Professional part
Typical Low
$66.07
Median
$173.78
Typical High
$309.03
Medica
Setting
Professional
Modifier
TC · Technical part
Typical Low
$208.93
Median
$660.69
Typical High
$2,187.76
United
Setting
Professional
Modifier
Global
Typical Low
$398.11
Median
$831.76
Typical High
$1,513.56
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$67.61
Median
$151.36
Typical High
$316.23
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$281.84
Median
$691.83
Typical High
$1,202.26

Where Minnesota sits

The same service costs 4.7 times more in Minnesota than in Rhode Island. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Minnesota $794 · 1st of 51
MN $794RI $170

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.