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In Situ Hybridization Tissue Test

Minnesota rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated October 2026.

How much does In Situ Hybridization Tissue Test cost?

$692

Typical negotiated rate. In Minnesota, October 2026.

Insurers have agreed to pay about $692 for this service. The price depends on where it is billed: about $661 from a physician practice, and about $692 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$661$513 to $1,023
FacilityA hospital or hospital-owned outpatient department$692$631 to $1,318

How much rates vary

Facilitymedian $692 · 10th to 90th $363 to $1,995Professionalmedian $661 · 10th to 90th $363 to $1,380
$200$500$1K$2Kfacility $692professional $661

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$363.08
Median
$691.83
Typical High
$1,995.26
Aetna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$57.54
Median
$57.54
Typical High
$57.54
Aetna
Setting
Facility
Modifier
TC · Technical part
Typical Low
$302.00
Median
$302.00
Typical High
$302.00
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$309.03
Median
$363.08
Typical High
$436.52
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$57.54
Median
$57.54
Typical High
$70.79
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$257.04
Median
$302.00
Typical High
$316.23
BCBS Minnesota
Setting
Facility
Modifier
None
Typical Low
$162.18
Median
$331.13
Typical High
$660.69
BCBS Minnesota
Setting
Professional
Modifier
None (both parts)
Typical Low
$537.03
Median
$891.25
Typical High
$1,412.54
BCBS Minnesota
Setting
Professional
Modifier
26 · Professional part
Typical Low
$85.11
Median
$144.54
Typical High
$229.09
BCBS Minnesota
Setting
Professional
Modifier
TC · Technical part
Typical Low
$436.52
Median
$776.25
Typical High
$1,202.26
Cigna
Setting
Facility
Modifier
None
Typical Low
$870.96
Median
$1,348.96
Typical High
$3,981.07
Cigna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$134.90
Median
$213.80
Typical High
$630.96
Cigna
Setting
Facility
Modifier
TC · Technical part
Typical Low
$724.44
Median
$1,148.15
Typical High
$3,311.31
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$524.81
Median
$575.44
Typical High
$758.58
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$83.18
Median
$91.20
Typical High
$120.23
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$436.52
Median
$478.63
Typical High
$645.65
Health Partners
Setting
Facility
Modifier
None
Typical Low
$794.33
Median
$1,318.26
Typical High
$3,162.28
Health Partners
Setting
Facility
Modifier
26 · Professional part
Typical Low
$125.89
Median
$208.93
Typical High
$489.78
Health Partners
Setting
Facility
Modifier
TC · Technical part
Typical Low
$676.08
Median
$1,096.48
Typical High
$2,630.27
Health Partners
Setting
Professional
Modifier
None (both parts)
Typical Low
$512.86
Median
$512.86
Typical High
$724.44
Health Partners
Setting
Professional
Modifier
26 · Professional part
Typical Low
$81.28
Median
$81.28
Typical High
$114.82
Health Partners
Setting
Professional
Modifier
TC · Technical part
Typical Low
$436.52
Median
$436.52
Typical High
$616.60
Medica
Setting
Facility
Modifier
None
Typical Low
$309.03
Median
$645.65
Typical High
$1,230.27
Medica
Setting
Professional
Modifier
None (both parts)
Typical Low
$331.13
Median
$870.96
Typical High
$2,570.40
Medica
Setting
Professional
Modifier
26 · Professional part
Typical Low
$67.61
Median
$177.83
Typical High
$398.11
Medica
Setting
Professional
Modifier
TC · Technical part
Typical Low
$281.84
Median
$724.44
Typical High
$2,187.76
United
Setting
Facility
Modifier
None
Typical Low
$426.58
Median
$467.74
Typical High
$602.56
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$245.47
Median
$741.31
Typical High
$1,202.26
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$40.74
Median
$120.23
Typical High
$199.53
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$208.93
Median
$630.96
Typical High
$1,000.00
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$181.97
Median
$181.97
Typical High
$181.97
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$72.44
Median
$72.44
Typical High
$72.44
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$181.97
Median
$181.97
Typical High
$181.97
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$72.44
Median
$72.44
Typical High
$72.44

Where Minnesota sits

The same service costs 9.1 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Minnesota· 2nd of 51

$692

AK $891AL $97.72

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.