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In Situ Hybridization Tissue Test

Alabama rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated October 2026.

How much does In Situ Hybridization Tissue Test cost?

$97.72

Typical negotiated rate. In Alabama, October 2026.

Insurers have agreed to pay about $97.72 for this service. The price depends on where it is billed: about $245 from a physician practice, and about $58.88 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$245$170 to $380
FacilityA hospital or hospital-owned outpatient department$58.88$58.88 to $58.88

How much rates vary

Facilitymedian $59 · 10th to 90th $59 to $269Professionalmedian $245 · 10th to 90th $98 to $380
$100$200$500$1Kfacility $59professional $245

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$338.84
Median
$380.19
Typical High
$380.19
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$199.53
Median
$380.19
Typical High
$380.19
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$38.90
Median
$67.61
Typical High
$67.61
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$169.82
Median
$316.23
Typical High
$316.23
Ambetter
Setting
Professional
Modifier
26 · Professional part
Typical Low
$81.28
Median
$81.28
Typical High
$81.28
BCBS Alabama
Setting
Facility
Modifier
None
Typical Low
$58.88
Median
$58.88
Typical High
$58.88
BCBS Alabama
Setting
Professional
Modifier
12 + 32 · Mandated service + 81 · Minimal assistant surgeon
Typical Low
$70.79
Median
$338.84
Typical High
$407.38
Cigna
Setting
Facility
Modifier
None
Typical Low
$257.04
Median
$269.15
Typical High
$1,000.00
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$97.72
Median
$97.72
Typical High
$269.15
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$31.62
Median
$31.62
Typical High
$102.33
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$66.07
Median
$66.07
Typical High
$173.78
United
Setting
Facility
Modifier
None
Typical Low
$199.53
Median
$204.17
Typical High
$275.42
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$169.82
Median
$223.87
Typical High
$407.38
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$38.90
Median
$56.23
Typical High
$67.61
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$112.20
Median
$181.97
Typical High
$346.74
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$144.54
Median
$190.55
Typical High
$190.55
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$57.54
Median
$75.86
Typical High
$75.86

Where Alabama sits

The same service costs 9.1 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Alabama· 51st of 51

$97.72

AK $891AL $97.72

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.