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In Situ Hybridization Tissue Test

Nebraska rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated October 2026.

How much does In Situ Hybridization Tissue Test cost?

$468

Typical negotiated rate. In Nebraska, October 2026.

Insurers have agreed to pay about $468 for this service. The price depends on where it is billed: about $589 from a physician practice, and about $229 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$589$380 to $759
FacilityA hospital or hospital-owned outpatient department$229$195 to $427

How much rates vary

Facilitymedian $229 · 10th to 90th $155 to $1,072Professionalmedian $589 · 10th to 90th $229 to $2,570
$100$200$500$1K$2Kfacility $229professional $589

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$229.09
Median
$229.09
Typical High
$229.09
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$199.53
Median
$229.09
Typical High
$269.15
Ambetter
Setting
Professional
Modifier
26 · Professional part
Typical Low
$147.91
Median
$147.91
Typical High
$147.91
BCBS Nebraska
Setting
Facility
Modifier
None
Typical Low
$114.82
Median
$204.17
Typical High
$436.52
BCBS Nebraska
Setting
Professional
Modifier
26 · Professional part
Typical Low
$85.11
Median
$95.50
Typical High
$97.72
BCBS Nebraska
Setting
Professional
Modifier
TC · Technical part
Typical Low
$416.87
Median
$478.63
Typical High
$501.19
Cigna
Setting
Facility
Modifier
None
Typical Low
$2,137.96
Median
$2,137.96
Typical High
$2,137.96
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$575.44
Median
$691.83
Typical High
$933.25
Medica
Setting
Facility
Modifier
None
Typical Low
$213.80
Median
$323.59
Typical High
$1,778.28
Medica
Setting
Professional
Modifier
None (both parts)
Typical Low
$371.54
Median
$575.44
Typical High
$2,570.40
Medica
Setting
Professional
Modifier
26 · Professional part
Typical Low
$64.57
Median
$128.82
Typical High
$398.11
Medica
Setting
Professional
Modifier
TC · Technical part
Typical Low
$263.03
Median
$389.05
Typical High
$2,187.76
Midlands
Setting
Professional
Modifier
None
Typical Low
$630.96
Median
$676.08
Typical High
$954.99
Midlands
Setting
Facility
Modifier
None
Typical Low
$2,137.96
Median
$2,137.96
Typical High
$2,137.96
Midlands
Setting
Professional
Modifier
None (both parts)
Typical Low
$630.96
Median
$776.25
Typical High
$954.99
United
Setting
Facility
Modifier
None
Typical Low
$213.80
Median
$229.09
Typical High
$288.40
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$346.74
Median
$380.19
Typical High
$660.69
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$57.54
Median
$66.07
Typical High
$190.55
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$281.84
Median
$309.03
Typical High
$549.54

Where Nebraska sits

The same service costs 9.1 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Nebraska· 15th of 51

$468

AK $891AL $97.72

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.