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In Situ Hybridization Tissue Test

Nebraska rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated July 2026.

How much does In Situ Hybridization Tissue Test cost?

$245

Typical negotiated rate. In Nebraska, July 2026.

Insurers have agreed to pay about $245 for this service. Most negotiated rates run $245 to $589.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $245 · 10th to 90th $229 to $871
$200.0$500.0$1.0K$2.0Kprofessional $245

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
Global
Typical Low
$229.09
Median
$245.47
Typical High
$245.47
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$40.74
Median
$58.88
Typical High
$162.18
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$162.18
Median
$204.17
Typical High
$204.17
Ambetter
Setting
Professional
Modifier
26 · Professional part
Typical Low
$147.91
Median
$147.91
Typical High
$147.91
BCBS
Setting
Professional
Modifier
Global
Typical Low
$398.11
Median
$588.84
Typical High
$602.56
BCBS
Setting
Professional
Modifier
26 · Professional part
Typical Low
$66.07
Median
$97.72
Typical High
$97.72
BCBS
Setting
Professional
Modifier
TC · Technical part
Typical Low
$338.84
Median
$501.19
Typical High
$501.19
Cigna
Setting
Professional
Modifier
Global
Typical Low
$575.44
Median
$676.08
Typical High
$933.25
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$95.50
Median
$114.82
Typical High
$158.49
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$478.63
Median
$562.34
Typical High
$776.25
Medica
Setting
Professional
Modifier
Global
Typical Low
$199.53
Median
$380.19
Typical High
$2,570.40
Medica
Setting
Professional
Modifier
26 · Professional part
Typical Low
$61.66
Median
$66.07
Typical High
$398.11
Medica
Setting
Professional
Modifier
TC · Technical part
Typical Low
$134.90
Median
$309.03
Typical High
$2,187.76
Midlands
Setting
Professional
Modifier
Global
Typical Low
$660.69
Median
$676.08
Typical High
$933.25
Midlands
Setting
Professional
Modifier
26 · Professional part
Typical Low
$109.65
Median
$120.23
Typical High
$158.49
Midlands
Setting
Professional
Modifier
TC · Technical part
Typical Low
$549.54
Median
$562.34
Typical High
$776.25
Midlands
Setting
Professional
Modifier
Global
Typical Low
$870.96
Median
$870.96
Typical High
$933.25
Midlands
Setting
Professional
Modifier
26 · Professional part
Typical Low
$138.04
Median
$144.54
Typical High
$158.49
Midlands
Setting
Professional
Modifier
TC · Technical part
Typical Low
$724.44
Median
$724.44
Typical High
$776.25
United
Setting
Professional
Modifier
Global
Typical Low
$229.09
Median
$380.19
Typical High
$741.31
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$57.54
Median
$66.07
Typical High
$190.55
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$186.21
Median
$309.03
Typical High
$616.60

Where Nebraska sits

The same service costs 4.7 times more in Minnesota than in Rhode Island. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Nebraska $245 · 48th of 51
MN $794RI $170

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.