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In Situ Hybridization Tissue Test

North Carolina rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated October 2026.

How much does In Situ Hybridization Tissue Test cost?

$302

Typical negotiated rate. In North Carolina, October 2026.

Insurers have agreed to pay about $302 for this service. The price depends on where it is billed: about $302 from a physician practice, and about $468 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$302$204 to $372
FacilityA hospital or hospital-owned outpatient department$468$309 to $955

How much rates vary

Facilitymedian $468 · 10th to 90th $263 to $1,445Professionalmedian $302 · 10th to 90th $107 to $575
$100$200$500$1Kfacility $468professional $302

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$309.03
Median
$309.03
Typical High
$602.56
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$218.78
Median
$309.03
Typical High
$602.56
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$47.86
Median
$50.12
Typical High
$97.72
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$169.82
Median
$257.04
Typical High
$457.09
Ambetter
Setting
Professional
Modifier
26 · Professional part
Typical Low
$66.07
Median
$112.20
Typical High
$112.20
BCBS North Carolina
Setting
Facility
Modifier
None
Typical Low
$1,318.26
Median
$1,318.26
Typical High
$1,318.26
BCBS North Carolina
Setting
Professional
Modifier
26 · Professional part
Typical Low
$60.26
Median
$123.03
Typical High
$169.82
BCBS North Carolina
Setting
Professional
Modifier
TC · Technical part
Typical Low
$120.23
Median
$239.88
Typical High
$478.63
Cigna
Setting
Facility
Modifier
None
Typical Low
$245.47
Median
$691.83
Typical High
$1,445.44
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$107.15
Median
$190.55
Typical High
$537.03
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$31.62
Median
$33.88
Typical High
$123.03
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$72.44
Median
$158.49
Typical High
$398.11
Medcost
Setting
Facility
Modifier
None
Typical Low
$309.03
Median
$309.03
Typical High
$426.58
Medcost
Setting
Professional
Modifier
None (both parts)
Typical Low
$302.00
Median
$302.00
Typical High
$467.74
Medcost
Setting
Professional
Modifier
26 · Professional part
Typical Low
$95.50
Median
$95.50
Typical High
$100.00
Medcost
Setting
Professional
Modifier
TC · Technical part
Typical Low
$208.93
Median
$208.93
Typical High
$398.11
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$181.97
Median
$239.88
Typical High
$660.69
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$36.31
Median
$61.66
Typical High
$117.49
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$97.72
Median
$199.53
Typical High
$549.54
7 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$144.54
Median
$154.88
Typical High
$181.97
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$57.54
Median
$61.66
Typical High
$72.44
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$151.36
Median
$151.36
Typical High
$323.59
Medcost
Setting
Professional
Modifier
80 · Assistant surgeon
Typical Low
$60.26
Median
$60.26
Typical High
$128.82
Medcost
Setting
Professional
Modifier
81 · Minimal assistant surgeon
Typical Low
$42.66
Median
$42.66
Typical High
$91.20
Medcost
Setting
Professional
Modifier
82 · Assistant surgeon, no resident
Typical Low
$42.66
Median
$42.66
Typical High
$91.20
Medcost
Setting
Professional
Modifier
AS · PA/NP assist
Typical Low
$42.66
Median
$42.66
Typical High
$91.20

Where North Carolina sits

The same service costs 9.1 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

North Carolina· 37th of 51

$302

AK $891AL $97.72

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.