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In Situ Hybridization Tissue Test

North Carolina rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated July 2026.

How much does In Situ Hybridization Tissue Test cost?

$309

Typical negotiated rate. In North Carolina, July 2026.

Insurers have agreed to pay about $309 for this service. Most negotiated rates run $234 to $372.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $309 · 10th to 90th $219 to $646
$100.0$200.0$500.0$1.0K$2.0Kprofessional $309

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$41.69
Median
$52.48
Typical High
$95.50
Aetna
Setting
Professional
Modifier
Global
Typical Low
$218.78
Median
$309.03
Typical High
$645.65
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$42.66
Median
$58.88
Typical High
$141.25
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$158.49
Median
$257.04
Typical High
$426.58
Ambetter
Setting
Professional
Modifier
26 · Professional part
Typical Low
$66.07
Median
$66.07
Typical High
$112.20
BCBS
Setting
Professional
Modifier
26 · Professional part
Typical Low
$53.70
Median
$109.65
Typical High
$123.03
BCBS
Setting
Professional
Modifier
TC · Technical part
Typical Low
$120.23
Median
$251.19
Typical High
$380.19
Cigna
Setting
Professional
Modifier
Global
Typical Low
$107.15
Median
$199.53
Typical High
$537.03
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$30.90
Median
$35.48
Typical High
$109.65
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$72.44
Median
$162.18
Typical High
$416.87
Medcost
Setting
Professional
Modifier
Global
Typical Low
$72.44
Median
$72.44
Typical High
$72.44
United
Setting
Professional
Modifier
Global
Typical Low
$141.25
Median
$239.88
Typical High
$645.65
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$37.15
Median
$64.57
Typical High
$128.82
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$89.13
Median
$199.53
Typical High
$537.03
Wellcare
Setting
Facility
Modifier
26 · Professional part
Typical Low
$478.63
Median
$478.63
Typical High
$478.63
Wellcare
Setting
Professional
Modifier
Global
Typical Low
$2,570.40
Median
$2,570.40
Typical High
$3,235.94
Wellcare
Setting
Professional
Modifier
26 · Professional part
Typical Low
$512.86
Median
$512.86
Typical High
$512.86
Wellcare
Setting
Professional
Modifier
TC · Technical part
Typical Low
$2,187.76
Median
$2,187.76
Typical High
$2,754.23

Where North Carolina sits

The same service costs 4.7 times more in Minnesota than in Rhode Island. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

North Carolina $309 · 24th of 51
MN $794RI $170

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.