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In Situ Hybridization Tissue Test

South Carolina rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated October 2026.

How much does In Situ Hybridization Tissue Test cost?

$288

Typical negotiated rate. In South Carolina, October 2026.

Insurers have agreed to pay about $288 for this service. The price depends on where it is billed: about $302 from a physician practice, and about $224 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$302$229 to $389
FacilityA hospital or hospital-owned outpatient department$224$148 to $355

How much rates vary

Facilitymedian $224 · 10th to 90th $102 to $871Professionalmedian $302 · 10th to 90th $105 to $468
$50$100$200$500$1Kfacility $224professional $302

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$288.40
Median
$354.81
Typical High
$1,047.13
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$281.84
Median
$288.40
Typical High
$436.52
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$47.86
Median
$47.86
Typical High
$70.79
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$239.88
Median
$239.88
Typical High
$363.08
Ambetter
Setting
Professional
Modifier
26 · Professional part
Typical Low
$29.51
Median
$60.26
Typical High
$66.07
BCBS South Carolina
Setting
Facility
Modifier
None
Typical Low
$97.72
Median
$199.53
Typical High
$331.13
BCBS South Carolina
Setting
Facility
Modifier
TC · Technical part
Typical Low
$107.15
Median
$107.15
Typical High
$107.15
BCBS South Carolina
Setting
Professional
Modifier
None (both parts)
Typical Low
$338.84
Median
$354.81
Typical High
$436.52
BCBS South Carolina
Setting
Professional
Modifier
26 · Professional part
Typical Low
$60.26
Median
$117.49
Typical High
$151.36
BCBS South Carolina
Setting
Professional
Modifier
TC · Technical part
Typical Low
$223.87
Median
$281.84
Typical High
$302.00
Cigna
Setting
Facility
Modifier
None
Typical Low
$602.56
Median
$794.33
Typical High
$1,949.84
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$102.33
Median
$104.71
Typical High
$302.00
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$32.36
Median
$33.88
Typical High
$95.50
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$69.18
Median
$70.79
Typical High
$204.17
Medcost
Setting
Facility
Modifier
None
Typical Low
$288.40
Median
$346.74
Typical High
$1,047.13
Medcost
Setting
Professional
Modifier
None (both parts)
Typical Low
$302.00
Median
$302.00
Typical High
$436.52
Medcost
Setting
Professional
Modifier
26 · Professional part
Typical Low
$95.50
Median
$95.50
Typical High
$107.15
Medcost
Setting
Professional
Modifier
TC · Technical part
Typical Low
$204.17
Median
$204.17
Typical High
$537.03
Molina
Setting
Professional
Modifier
None (both parts)
Typical Low
$33.11
Median
$309.03
Typical High
$467.74
United
Setting
Facility
Modifier
None
Typical Low
$707.95
Median
$870.96
Typical High
$1,122.02
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$190.55
Median
$288.40
Typical High
$602.56
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$37.15
Median
$67.61
Typical High
$162.18
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$134.90
Median
$223.87
Typical High
$478.63
5 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$147.91
Median
$147.91
Typical High
$275.42
Medcost
Setting
Professional
Modifier
80 · Assistant surgeon
Typical Low
$60.26
Median
$60.26
Typical High
$109.65
Medcost
Setting
Professional
Modifier
81 · Minimal assistant surgeon
Typical Low
$41.69
Median
$41.69
Typical High
$77.62
Medcost
Setting
Professional
Modifier
82 · Assistant surgeon, no resident
Typical Low
$41.69
Median
$41.69
Typical High
$77.62
Medcost
Setting
Professional
Modifier
AS · PA/NP assist
Typical Low
$41.69
Median
$41.69
Typical High
$77.62

Where South Carolina sits

The same service costs 9.1 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Carolina· 45th of 51

$288

AK $891AL $97.72

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.