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In Situ Hybridization Tissue Test

South Carolina rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated July 2026.

How much does In Situ Hybridization Tissue Test cost?

$295

Typical negotiated rate. In South Carolina, July 2026.

Insurers have agreed to pay about $295 for this service. Most negotiated rates run $251 to $398.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $295 · 10th to 90th $191 to $646
$50$100$200$500professional $295

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
Global
Typical Low
$190.55
Median
$295.12
Typical High
$645.65
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$47.86
Median
$58.88
Typical High
$218.78
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$131.83
Median
$239.88
Typical High
$389.05
Ambetter
Setting
Professional
Modifier
26 · Professional part
Typical Low
$29.51
Median
$60.26
Typical High
$66.07
BCBS
Setting
Professional
Modifier
Global
Typical Low
$338.84
Median
$371.54
Typical High
$691.83
BCBS
Setting
Professional
Modifier
26 · Professional part
Typical Low
$60.26
Median
$117.49
Typical High
$239.88
BCBS
Setting
Professional
Modifier
TC · Technical part
Typical Low
$223.87
Median
$281.84
Typical High
$446.68
Cigna
Setting
Professional
Modifier
Global
Typical Low
$100.00
Median
$181.97
Typical High
$398.11
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$30.90
Median
$33.88
Typical High
$95.50
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$67.61
Median
$128.82
Typical High
$331.13
Molina
Setting
Professional
Modifier
Global
Typical Low
$32.36
Median
$32.36
Typical High
$33.11
United
Setting
Professional
Modifier
Global
Typical Low
$120.23
Median
$288.40
Typical High
$602.56
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$37.15
Median
$85.11
Typical High
$316.23
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$81.28
Median
$208.93
Typical High
$478.63

Where South Carolina sits

The same service costs 4.7 times more in Minnesota than in Rhode Island. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Carolina· 34th of 51

$295

MN $794RI $170

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.