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In Situ Hybridization Tissue Test

Iowa rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated October 2026.

How much does In Situ Hybridization Tissue Test cost?

$513

Typical negotiated rate. In Iowa, October 2026.

Insurers have agreed to pay about $513 for this service. The price depends on where it is billed: about $525 from a physician practice, and about $457 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$525$135 to $692
FacilityA hospital or hospital-owned outpatient department$457$275 to $575

How much rates vary

Facilitymedian $457 · 10th to 90th $257 to $794Professionalmedian $525 · 10th to 90th $107 to $832
$100$200$500$1K$2Kfacility $457professional $525

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$257.04
Median
$269.15
Typical High
$354.81
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$263.03
Median
$269.15
Typical High
$562.34
Cigna
Setting
Facility
Modifier
None
Typical Low
$724.44
Median
$724.44
Typical High
$724.44
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$208.93
Median
$691.83
Typical High
$912.01
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$61.66
Median
$109.65
Typical High
$162.18
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$154.88
Median
$575.44
Typical High
$741.31
Hally Health
Setting
Professional
Modifier
None
Typical Low
$295.12
Median
$524.81
Typical High
$891.25
Medica
Setting
Facility
Modifier
None
Typical Low
$257.04
Median
$512.86
Typical High
$912.01
Medica
Setting
Professional
Modifier
None (both parts)
Typical Low
$380.19
Median
$676.08
Typical High
$2,570.40
Medica
Setting
Professional
Modifier
26 · Professional part
Typical Low
$66.07
Median
$213.80
Typical High
$398.11
Medica
Setting
Professional
Modifier
TC · Technical part
Typical Low
$309.03
Median
$758.58
Typical High
$2,187.76
Midlands
Setting
Professional
Modifier
None
Typical Low
$660.69
Median
$691.83
Typical High
$1,047.13
Midlands
Setting
Facility
Modifier
None
Typical Low
$724.44
Median
$724.44
Typical High
$724.44
Midlands
Setting
Professional
Modifier
None (both parts)
Typical Low
$724.44
Median
$724.44
Typical High
$741.31
Oscar Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$66.07
Median
$389.05
Typical High
$758.58
United
Setting
Facility
Modifier
None
Typical Low
$257.04
Median
$426.58
Typical High
$537.03
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$380.19
Median
$407.38
Typical High
$891.25
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$64.57
Median
$69.18
Typical High
$173.78
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$309.03
Median
$331.13
Typical High
$645.65
Wellmark
Setting
Professional
Modifier
None (both parts)
Typical Low
$794.33
Median
$851.14
Typical High
$912.01
Wellmark
Setting
Professional
Modifier
26 · Professional part
Typical Low
$125.89
Median
$138.04
Typical High
$147.91
Wellmark
Setting
Professional
Modifier
TC · Technical part
Typical Low
$676.08
Median
$707.95
Typical High
$758.58

Where Iowa sits

The same service costs 9.1 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Iowa· 12th of 51

$513

AK $891AL $97.72

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.