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In Situ Hybridization Tissue Test

Iowa rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated July 2026.

How much does In Situ Hybridization Tissue Test cost?

$355

Typical negotiated rate. In Iowa, July 2026.

Insurers have agreed to pay about $355 for this service. Most negotiated rates run $282 to $631.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $355 · 10th to 90th $66 to $759
$100$200$500$1Kprofessional $355

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
Global
Typical Low
$281.84
Median
$331.13
Typical High
$371.54
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$46.77
Median
$53.70
Typical High
$67.61
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$234.42
Median
$281.84
Typical High
$309.03
Cigna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$36.31
Median
$169.82
Typical High
$245.47
Cigna
Setting
Professional
Modifier
Global
Typical Low
$186.21
Median
$660.69
Typical High
$912.01
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$48.98
Median
$120.23
Typical High
$162.18
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$144.54
Median
$537.03
Typical High
$741.31
Hally Health
Setting
Professional
Modifier
Global
Typical Low
$295.12
Median
$616.60
Typical High
$891.25
Hally Health
Setting
Professional
Modifier
26 · Professional part
Typical Low
$50.12
Median
$104.71
Typical High
$251.19
Hally Health
Setting
Professional
Modifier
TC · Technical part
Typical Low
$245.47
Median
$436.52
Typical High
$645.65
Medica
Setting
Facility
Modifier
26 · Professional part
Typical Low
$281.84
Median
$281.84
Typical High
$281.84
Medica
Setting
Professional
Modifier
Global
Typical Low
$204.17
Median
$616.60
Typical High
$2,570.40
Medica
Setting
Professional
Modifier
26 · Professional part
Typical Low
$64.57
Median
$102.33
Typical High
$398.11
Medica
Setting
Professional
Modifier
TC · Technical part
Typical Low
$138.04
Median
$346.74
Typical High
$2,187.76
Midlands
Setting
Professional
Modifier
Global
Typical Low
$426.58
Median
$660.69
Typical High
$812.83
Midlands
Setting
Professional
Modifier
26 · Professional part
Typical Low
$74.13
Median
$125.89
Typical High
$257.04
Midlands
Setting
Professional
Modifier
TC · Technical part
Typical Low
$295.12
Median
$537.03
Typical High
$691.83
Midlands
Setting
Professional
Modifier
Global
Typical Low
$724.44
Median
$724.44
Typical High
$724.44
Midlands
Setting
Professional
Modifier
26 · Professional part
Typical Low
$128.82
Median
$128.82
Typical High
$128.82
Midlands
Setting
Professional
Modifier
TC · Technical part
Typical Low
$588.84
Median
$588.84
Typical High
$588.84
Oscar Health
Setting
Professional
Modifier
Global
Typical Low
$64.57
Median
$354.81
Typical High
$724.44
United
Setting
Professional
Modifier
Global
Typical Low
$380.19
Median
$407.38
Typical High
$891.25
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$66.07
Median
$109.65
Typical High
$269.15
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$309.03
Median
$346.74
Typical High
$691.83
Wellmark
Setting
Professional
Modifier
Global
Typical Low
$676.08
Median
$794.33
Typical High
$870.96
Wellmark
Setting
Professional
Modifier
26 · Professional part
Typical Low
$107.15
Median
$125.89
Typical High
$138.04
Wellmark
Setting
Professional
Modifier
TC · Technical part
Typical Low
$575.44
Median
$676.08
Typical High
$724.44

Where Iowa sits

The same service costs 4.7 times more in Minnesota than in Rhode Island. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Iowa· 17th of 51

$355

MN $794RI $170

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.