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In Situ Hybridization Tissue Test

Illinois rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated July 2026.

Facilitymedian $170 · 10th–90th $170$1700%50%100%$170Professionalmedian $257 · 10th–90th $52$5130%10%10th90th$257$5.0$20.0$100.0$500.0$2.0K

Distribution of negotiated rates across all payers (price axis is log-scale). Facility and professional rates are different services and are charted separately. Small sample; interpret with caution. Need provider-level prices? Contact us.

Insurance Carrier
Aetna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$169.82
Median
$169.82
Typical High
$169.82
Aetna
Setting
Professional
Modifier
Global
Typical Low
$251.19
Median
$338.84
Typical High
$512.86
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$47.86
Median
$54.95
Typical High
$141.25
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$147.91
Median
$288.40
Typical High
$467.74
Ambetter
Setting
Professional
Modifier
26 · Professional part
Typical Low
$27.54
Median
$29.51
Typical High
$61.66
BCBS
Setting
Professional
Modifier
Global
Typical Low
$67.61
Median
$190.55
Typical High
$575.44
Cigna
Setting
Professional
Modifier
Global
Typical Low
$117.49
Median
$199.53
Typical High
$630.96
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$29.51
Median
$35.48
Typical High
$102.33
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$83.18
Median
$169.82
Typical High
$537.03
Hally Health
Setting
Professional
Modifier
Global
Typical Low
$416.87
Median
$645.65
Typical High
$1,258.93
Hally Health
Setting
Professional
Modifier
26 · Professional part
Typical Low
$67.61
Median
$107.15
Typical High
$363.08
Hally Health
Setting
Professional
Modifier
TC · Technical part
Typical Low
$316.23
Median
$501.19
Typical High
$1,071.52
Molina
Setting
Professional
Modifier
Global
Typical Low
$32.36
Median
$32.36
Typical High
$33.11
United
Setting
Professional
Modifier
Global
Typical Low
$213.80
Median
$380.19
Typical High
$676.08
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$41.69
Median
$85.11
Typical High
$257.04
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$147.91
Median
$309.03
Typical High
$562.34