go back

In Situ Hybridization Tissue Test

Massachusetts rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated July 2026.

How much does In Situ Hybridization Tissue Test cost?

$490

Typical negotiated rate. In Massachusetts, July 2026.

Insurers have agreed to pay about $490 for this service. Most negotiated rates run $257 to $851.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $490 · 10th to 90th $170 to $1,023
$50.0$100.0$200.0$500.0$1.0K$2.0Kprofessional $490

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
Global
Typical Low
$169.82
Median
$257.04
Typical High
$724.44
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$42.66
Median
$144.54
Typical High
$208.93
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$120.23
Median
$154.88
Typical High
$630.96
AllWays Health Partners
Setting
Facility
Modifier
26 · Professional part
Typical Low
$478.63
Median
$478.63
Typical High
$478.63
AllWays Health Partners
Setting
Professional
Modifier
Global
Typical Low
$229.09
Median
$524.81
Typical High
$2,570.40
AllWays Health Partners
Setting
Professional
Modifier
26 · Professional part
Typical Low
$45.71
Median
$91.20
Typical High
$512.86
AllWays Health Partners
Setting
Professional
Modifier
TC · Technical part
Typical Low
$208.93
Median
$478.63
Typical High
$2,187.76
BCBS
Setting
Professional
Modifier
Global
Typical Low
$489.78
Median
$831.76
Typical High
$1,096.48
BCBS
Setting
Professional
Modifier
26 · Professional part
Typical Low
$85.11
Median
$123.03
Typical High
$162.18
BCBS
Setting
Professional
Modifier
TC · Technical part
Typical Low
$524.81
Median
$707.95
Typical High
$954.99
Cigna
Setting
Professional
Modifier
Global
Typical Low
$213.80
Median
$323.59
Typical High
$724.44
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$32.36
Median
$60.26
Typical High
$131.83
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$190.55
Median
$275.42
Typical High
$691.83
Fallon Health
Setting
Professional
Modifier
Global
Typical Low
$75.86
Median
$446.68
Typical High
$741.31
Harvard Pilgrim
Setting
Professional
Modifier
Global
Typical Low
$467.74
Median
$794.33
Typical High
$1,096.48
Harvard Pilgrim
Setting
Professional
Modifier
26 · Professional part
Typical Low
$74.13
Median
$125.89
Typical High
$173.78
Harvard Pilgrim
Setting
Professional
Modifier
TC · Technical part
Typical Low
$389.05
Median
$676.08
Typical High
$933.25
Health New England
Setting
Professional
Modifier
Global
Typical Low
$151.36
Median
$151.36
Typical High
$151.36
Mass General Brigham
Setting
Facility
Modifier
26 · Professional part
Typical Low
$478.63
Median
$478.63
Typical High
$478.63
Mass General Brigham
Setting
Professional
Modifier
Global
Typical Low
$229.09
Median
$524.81
Typical High
$2,570.40
Mass General Brigham
Setting
Professional
Modifier
26 · Professional part
Typical Low
$45.71
Median
$91.20
Typical High
$512.86
Mass General Brigham
Setting
Professional
Modifier
TC · Technical part
Typical Low
$208.93
Median
$478.63
Typical High
$2,187.76
United
Setting
Professional
Modifier
Global
Typical Low
$251.19
Median
$575.44
Typical High
$1,174.90
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$48.98
Median
$95.50
Typical High
$186.21
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$208.93
Median
$501.19
Typical High
$977.24

Where Massachusetts sits

The same service costs 4.7 times more in Minnesota than in Rhode Island. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Massachusetts $490 · 9th of 51
MN $794RI $170

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.