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In Situ Hybridization Tissue Test

Mississippi rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated October 2026.

How much does In Situ Hybridization Tissue Test cost?

$372

Typical negotiated rate. In Mississippi, October 2026.

Insurers have agreed to pay about $372 for this service. The price depends on where it is billed: about $372 from a physician practice, and about $372 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$372$191 to $550
FacilityA hospital or hospital-owned outpatient department$372$372 to $372

How much rates vary

Facilitymedian $372 · 10th to 90th $295 to $372Professionalmedian $372 · 10th to 90th $102 to $631
$50$100$200$500$1Kfacility $372professional $372

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$346.74
Median
$346.74
Typical High
$588.84
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$346.74
Median
$588.84
Typical High
$660.69
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$61.66
Median
$104.71
Typical High
$117.49
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$288.40
Median
$478.63
Typical High
$549.54
Ambetter
Setting
Professional
Modifier
None (both parts)
Typical Low
$190.55
Median
$190.55
Typical High
$190.55
BCBS Mississippi
Setting
Facility
Modifier
None
Typical Low
$371.54
Median
$371.54
Typical High
$371.54
BCBS Mississippi
Setting
Professional
Modifier
None (both parts)
Typical Low
$371.54
Median
$371.54
Typical High
$371.54
Cigna
Setting
Facility
Modifier
None
Typical Low
$223.87
Median
$239.88
Typical High
$295.12
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$173.78
Median
$239.88
Typical High
$602.56
Molina
Setting
Professional
Modifier
None (both parts)
Typical Low
$33.11
Median
$33.11
Typical High
$33.11
United
Setting
Facility
Modifier
None
Typical Low
$213.80
Median
$309.03
Typical High
$346.74
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$162.18
Median
$407.38
Typical High
$660.69
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$39.81
Median
$67.61
Typical High
$141.25
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$109.65
Median
$295.12
Typical High
$549.54
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$173.78
Median
$295.12
Typical High
$331.13
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$70.79
Median
$117.49
Typical High
$131.83

Where Mississippi sits

The same service costs 9.1 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Mississippi· 25th of 51

$372

AK $891AL $97.72

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.