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In Situ Hybridization Tissue Test

Indiana rates for HCPCS 88377

This laboratory test applies a labeled genetic probe directly to a tissue sample taken during a biopsy or surgery, allowing a pathologist to detect a specific gene or genetic sequence within the cells using microscopy. The results help confirm a diagnosis, such as determining the type of a tumor or the source of abnormal cells, and can guide decisions about treatment.

Rates data updated July 2026.

How much does In Situ Hybridization Tissue Test cost?

$302

Typical negotiated rate. In Indiana, July 2026.

Insurers have agreed to pay about $302 for this service. Most negotiated rates run $269 to $302.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $302 · 10th to 90th $132 to $339
$100$200$500professional $302

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
Global
Typical Low
$269.15
Median
$302.00
Typical High
$331.13
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$47.86
Median
$50.12
Typical High
$67.61
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$245.47
Median
$251.19
Typical High
$281.84
Ambetter
Setting
Professional
Modifier
26 · Professional part
Typical Low
$29.51
Median
$29.51
Typical High
$38.02
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$95.50
Median
$112.20
Typical High
$194.98
Anthem BCBS
Setting
Professional
Modifier
26 · Professional part
Typical Low
$26.92
Median
$26.92
Typical High
$63.10
Anthem BCBS
Setting
Professional
Modifier
TC · Technical part
Typical Low
$67.61
Median
$75.86
Typical High
$141.25
CareSource
Setting
Professional
Modifier
Global
Typical Low
$64.57
Median
$338.84
Typical High
$436.52
Cigna
Setting
Professional
Modifier
Global
Typical Low
$100.00
Median
$309.03
Typical High
$524.81
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$30.90
Median
$58.88
Typical High
$102.33
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$67.61
Median
$162.18
Typical High
$457.09
United
Setting
Professional
Modifier
Global
Typical Low
$194.98
Median
$380.19
Typical High
$691.83
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$40.74
Median
$74.13
Typical High
$120.23
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$131.83
Median
$316.23
Typical High
$575.44

Where Indiana sits

The same service costs 4.7 times more in Minnesota than in Rhode Island. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Indiana· 30th of 51

$302

MN $794RI $170

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.