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Biotinidase Enzyme Blood Test

Nationwide rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated July 2026.

Facilitymedian $30 · 10th–90th $14$890%10%10th90th$30Professionalmedian $15 · 10th–90th $9$370%20%10th90th$15$0.2$2.0$20.0$200.0$2.0K$20.0K

Distribution of negotiated rates across all payers (price axis is log-scale). Facility and professional rates are different services and are charted separately. Need provider-level prices? Contact us.

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$13.80
Median
$31.62
Typical High
$85.11
Aetna
Setting
Professional
Modifier
Global
Typical Low
$11.22
Median
$14.79
Typical High
$38.90
BCBS
Setting
Facility
Modifier
Global
Typical Low
$16.98
Median
$25.12
Typical High
$77.62
BCBS
Setting
Professional
Modifier
Global
Typical Low
$7.59
Median
$10.23
Typical High
$33.88
Cigna
Setting
Facility
Modifier
Global
Typical Low
$13.49
Median
$33.11
Typical High
$77.62
Cigna
Setting
Professional
Modifier
Global
Typical Low
$10.23
Median
$20.42
Typical High
$40.74
United
Setting
Facility
Modifier
Global
Typical Low
$8.51
Median
$16.98
Typical High
$24.55
United
Setting
Professional
Modifier
Global
Typical Low
$7.08
Median
$10.00
Typical High
$25.12