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Biotinidase Enzyme Blood Test

Maryland rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated July 2026.

How much does Biotinidase Enzyme Blood Test cost?

$13.80

Typical negotiated rate. In Maryland, July 2026.

Insurers have agreed to pay about $13.80 for this service. The price depends on where it is billed: about $12.88 from a physician practice, and about $158 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$12.88$12.59 to $20.89
FacilityA hospital or hospital-owned outpatient department$158$12.88 to $174

How much rates vary

Facilitymedian $158 · 10th to 90th $9 to $229Professionalmedian $13 · 10th to 90th $10 to $105
$5$10$20$50$100$200facility $158professional $13

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$158.49
Median
$173.78
Typical High
$229.09
Aetna
Setting
Professional
Modifier
Global
Typical Low
$11.22
Median
$14.13
Typical High
$104.71
CareFirst
Setting
Professional
Modifier
Global
Typical Low
$5.13
Median
$13.49
Typical High
$16.60
Cigna
Setting
Facility
Modifier
Global
Typical Low
$8.91
Median
$11.75
Typical High
$21.88
Cigna
Setting
Professional
Modifier
Global
Typical Low
$9.33
Median
$16.98
Typical High
$41.69
Kaiser Permanente
Setting
Professional
Modifier
Global
Typical Low
$15.85
Median
$19.50
Typical High
$25.12
United
Setting
Facility
Modifier
Global
Typical Low
$7.08
Median
$7.94
Typical High
$20.89
United
Setting
Professional
Modifier
Global
Typical Low
$7.08
Median
$10.00
Typical High
$15.14
Wellpoint
Setting
Professional
Modifier
Global
Typical Low
$6.61
Median
$11.75
Typical High
$25.12

Where Maryland sits

The same service costs 3.2 times more in Nebraska than in Washington, DC. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Maryland· 48th of 51

$13.80

NE $39.81DC $12.59

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.