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Biotinidase Enzyme Blood Test

Massachusetts rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated October 2026.

How much does Biotinidase Enzyme Blood Test cost?

$17.78

Typical negotiated rate. In Massachusetts, October 2026.

Insurers have agreed to pay about $17.78 for this service. The price depends on where it is billed: about $16.98 from a physician practice, and about $24.55 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$16.98$10.23 to $25.12
FacilityA hospital or hospital-owned outpatient department$24.55$15.49 to $40.74

How much rates vary

Facilitymedian $25 · 10th to 90th $13 to $59Professionalmedian $17 · 10th to 90th $9 to $44
$10$100$1Kfacility $25professional $17

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$10.23
Median
$28.84
Typical High
$47.86
Aetna
Setting
Professional
Modifier
None
Typical Low
$10.23
Median
$10.23
Typical High
$17.38
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$12.59
Median
$18.20
Typical High
$48.98
AllWays Health Partners
Setting
Professional
Modifier
None
Typical Low
$8.91
Median
$16.98
Typical High
$42.66
BCBS
Setting
Facility
Modifier
None
Typical Low
$14.79
Median
$41.69
Typical High
$60.26
BCBS
Setting
Professional
Modifier
None
Typical Low
$13.80
Median
$13.80
Typical High
$15.85
Cigna
Setting
Facility
Modifier
None
Typical Low
$10.96
Median
$23.99
Typical High
$43.65
Cigna
Setting
Professional
Modifier
None
Typical Low
$11.48
Median
$20.42
Typical High
$66.07
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$15.49
Median
$28.84
Typical High
$4,897.79
Fallon Health
Setting
Professional
Modifier
None
Typical Low
$24.55
Median
$24.55
Typical High
$28.84
Harvard Pilgrim
Setting
Professional
Modifier
None
Typical Low
$8.51
Median
$16.98
Typical High
$64.57
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$12.59
Median
$18.20
Typical High
$48.98
Mass General Brigham
Setting
Professional
Modifier
None
Typical Low
$8.91
Median
$16.98
Typical High
$42.66
United
Setting
Facility
Modifier
None
Typical Low
$15.14
Median
$16.98
Typical High
$20.42
United
Setting
Professional
Modifier
None
Typical Low
$6.76
Median
$10.00
Typical High
$35.48
Well Sense
Setting
Facility
Modifier
None
Typical Low
$11.22
Median
$18.62
Typical High
$29.51
Well Sense
Setting
Professional
Modifier
None
Typical Low
$11.22
Median
$11.22
Typical High
$13.49
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$5.13
Median
$5.13
Typical High
$8.71
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$2.04
Median
$2.04
Typical High
$3.55
Fallon Health
Setting
Facility
Modifier
QW · Waived lab test
Typical Low
$16.98
Median
$21.88
Typical High
$26.30

Where Massachusetts sits

The same service costs 18.6 times more in Kansas than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 21st of 51

$17.78

KS $53.70KY $2.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.