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Biotinidase Enzyme Blood Test

Massachusetts rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated July 2026.

Facilitymedian $39 · 10th–90th $15$830%10%10th90th$39Professionalmedian $17 · 10th–90th $10$410%20%40%10th90th$17$10.0$50.0$200.0$1.0K$5.0K$20.0K

Distribution of negotiated rates across all payers (price axis is log-scale). Facility and professional rates are different services and are charted separately. Need provider-level prices? Contact us.

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$14.79
Median
$29.51
Typical High
$85.11
Aetna
Setting
Professional
Modifier
Global
Typical Low
$10.23
Median
$15.14
Typical High
$47.86
AllWays Health Partners
Setting
Facility
Modifier
Global
Typical Low
$15.49
Median
$23.99
Typical High
$93.33
AllWays Health Partners
Setting
Professional
Modifier
Global
Typical Low
$8.91
Median
$16.98
Typical High
$40.74
BCBS
Setting
Facility
Modifier
Global
Typical Low
$33.11
Median
$41.69
Typical High
$60.26
BCBS
Setting
Professional
Modifier
Global
Typical Low
$13.80
Median
$15.85
Typical High
$15.85
Cigna
Setting
Facility
Modifier
Global
Typical Low
$11.75
Median
$26.92
Typical High
$43.65
Cigna
Setting
Professional
Modifier
Global
Typical Low
$10.47
Median
$19.50
Typical High
$44.67
Fallon Health
Setting
Facility
Modifier
Global
Typical Low
$12.30
Median
$85.11
Typical High
$7,079.46
Fallon Health
Setting
Professional
Modifier
Global
Typical Low
$24.55
Median
$24.55
Typical High
$28.84
Harvard Pilgrim
Setting
Professional
Modifier
Global
Typical Low
$16.98
Median
$16.98
Typical High
$36.31
Health New England
Setting
Facility
Modifier
Global
Typical Low
$81.28
Median
$81.28
Typical High
$81.28
Mass General Brigham
Setting
Facility
Modifier
Global
Typical Low
$15.49
Median
$23.99
Typical High
$93.33
Mass General Brigham
Setting
Professional
Modifier
Global
Typical Low
$8.91
Median
$16.98
Typical High
$40.74
United
Setting
Facility
Modifier
Global
Typical Low
$8.91
Median
$16.98
Typical High
$24.55
United
Setting
Professional
Modifier
Global
Typical Low
$8.91
Median
$16.98
Typical High
$42.66