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Biotinidase Enzyme Blood Test

Minnesota rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated October 2026.

How much does Biotinidase Enzyme Blood Test cost?

$19.50

Typical negotiated rate. In Minnesota, October 2026.

Insurers have agreed to pay about $19.50 for this service. The price depends on where it is billed: about $16.98 from a physician practice, and about $43.65 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$16.98$13.49 to $20.42
FacilityA hospital or hospital-owned outpatient department$43.65$16.98 to $77.62

How much rates vary

Facilitymedian $44 · 10th to 90th $16 to $288Professionalmedian $17 · 10th to 90th $12 to $32
$10$20$50$100$200facility $44professional $17

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$15.85
Median
$43.65
Typical High
$288.40
Aetna
Setting
Professional
Modifier
None
Typical Low
$15.49
Median
$15.85
Typical High
$20.42
BCBS
Setting
Facility
Modifier
None
Typical Low
$15.85
Median
$16.98
Typical High
$69.18
BCBS
Setting
Professional
Modifier
None
Typical Low
$13.49
Median
$15.14
Typical High
$16.98
Cigna
Setting
Facility
Modifier
None
Typical Low
$21.88
Median
$53.70
Typical High
$158.49
Cigna
Setting
Professional
Modifier
None
Typical Low
$19.50
Median
$24.55
Typical High
$32.36
Health Partners
Setting
Facility
Modifier
None
Typical Low
$31.62
Median
$52.48
Typical High
$123.03
Health Partners
Setting
Professional
Modifier
None
Typical Low
$19.50
Median
$19.50
Typical High
$32.36
Medica
Setting
Facility
Modifier
None
Typical Low
$20.42
Median
$33.88
Typical High
$93.33
Medica
Setting
Professional
Modifier
None
Typical Low
$8.51
Median
$14.13
Typical High
$38.90
United
Setting
Facility
Modifier
None
Typical Low
$16.98
Median
$16.98
Typical High
$20.42
United
Setting
Professional
Modifier
None
Typical Low
$7.08
Median
$14.45
Typical High
$39.81
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$7.94
Median
$7.94
Typical High
$7.94
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$3.16
Median
$3.16
Typical High
$3.16
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$7.94
Median
$7.94
Typical High
$10.00
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$3.16
Median
$3.16
Typical High
$4.07

Where Minnesota sits

The same service costs 18.6 times more in Kansas than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Minnesota· 15th of 51

$19.50

KS $53.70KY $2.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.