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Biotinidase Enzyme Blood Test

Illinois rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated October 2026.

How much does Biotinidase Enzyme Blood Test cost?

$12.88

Typical negotiated rate. In Illinois, October 2026.

Insurers have agreed to pay about $12.88 for this service. The price depends on where it is billed: about $12.88 from a physician practice, and about $37.15 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$12.88$10.72 to $13.80
FacilityA hospital or hospital-owned outpatient department$37.15$22.91 to $57.54

How much rates vary

Facilitymedian $37 · 10th to 90th $19 to $98Professionalmedian $13 · 10th to 90th $3 to $23
$5$10$20$50$100$200facility $37professional $13

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$13.80
Median
$20.42
Typical High
$51.29
Aetna
Setting
Professional
Modifier
None
Typical Low
$13.18
Median
$13.80
Typical High
$19.50
BCBS Illinois
Setting
Facility
Modifier
None
Typical Low
$21.38
Median
$37.15
Typical High
$173.78
BCBS Illinois
Setting
Professional
Modifier
None
Typical Low
$3.47
Median
$12.88
Typical High
$12.88
Cigna
Setting
Facility
Modifier
None
Typical Low
$19.05
Median
$38.90
Typical High
$70.79
Cigna
Setting
Professional
Modifier
None
Typical Low
$8.91
Median
$19.95
Typical High
$30.20
Hally Health
Setting
Professional
Modifier
None
Typical Low
$17.38
Median
$26.92
Typical High
$44.67
Hally Health
Setting
Facility
Modifier
None
Typical Low
$100.00
Median
$100.00
Typical High
$100.00
Hally Health
Setting
Professional
Modifier
None
Typical Low
$21.88
Median
$21.88
Typical High
$21.88
Molina
Setting
Professional
Modifier
None
Typical Low
$9.33
Median
$11.75
Typical High
$20.89
United
Setting
Facility
Modifier
None
Typical Low
$16.98
Median
$20.42
Typical High
$20.89
United
Setting
Professional
Modifier
None
Typical Low
$7.08
Median
$12.88
Typical High
$20.89
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$6.92
Median
$12.30
Typical High
$25.70
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$2.75
Median
$4.90
Typical High
$10.23
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$6.92
Median
$6.92
Typical High
$8.51
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$2.75
Median
$2.75
Typical High
$3.39

Where Illinois sits

The same service costs 18.6 times more in Kansas than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Illinois· 49th of 51

$12.88

KS $53.70KY $2.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.