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Biotinidase Enzyme Blood Test

North Carolina rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated July 2026.

How much does Biotinidase Enzyme Blood Test cost?

$15.14

Typical negotiated rate. In North Carolina, July 2026.

Insurers have agreed to pay about $15.14 for this service. The price depends on where it is billed: about $13.49 from a physician practice, and about $42.66 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$13.49$13.49 to $20.42
FacilityA hospital or hospital-owned outpatient department$42.66$14.79 to $56.23

How much rates vary

Facilitymedian $43 · 10th to 90th $13 to $93Professionalmedian $13 · 10th to 90th $11 to $22
$10$20$50$100facility $43professional $13

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$13.49
Median
$45.71
Typical High
$85.11
Aetna
Setting
Professional
Modifier
Global
Typical Low
$13.18
Median
$13.49
Typical High
$22.39
Ambetter
Setting
Professional
Modifier
Global
Typical Low
$11.75
Median
$11.75
Typical High
$11.75
BCBS
Setting
Facility
Modifier
Global
Typical Low
$35.48
Median
$72.44
Typical High
$72.44
BCBS
Setting
Professional
Modifier
Global
Typical Low
$7.59
Median
$10.96
Typical High
$15.49
Cigna
Setting
Facility
Modifier
Global
Typical Low
$11.75
Median
$32.36
Typical High
$77.62
Cigna
Setting
Professional
Modifier
Global
Typical Low
$8.71
Median
$11.75
Typical High
$25.70
Medcost
Setting
Professional
Modifier
Global
Typical Low
$14.13
Median
$30.90
Typical High
$102.33
Medcost
Setting
Facility
Modifier
Global
Typical Low
$13.49
Median
$15.14
Typical High
$33.11
Medcost
Setting
Professional
Modifier
Global
Typical Low
$4.37
Median
$4.37
Typical High
$4.79
Oscar Health
Setting
Facility
Modifier
Global
Typical Low
$302.00
Median
$302.00
Typical High
$302.00
United
Setting
Facility
Modifier
Global
Typical Low
$8.91
Median
$21.88
Typical High
$29.51
United
Setting
Professional
Modifier
Global
Typical Low
$8.51
Median
$11.75
Typical High
$23.44
Wellcare
Setting
Facility
Modifier
Global
Typical Low
$93.33
Median
$93.33
Typical High
$93.33

Where North Carolina sits

The same service costs 3.2 times more in Nebraska than in Washington, DC. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

North Carolina· 43rd of 51

$15.14

NE $39.81DC $12.59

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.