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Biotinidase Enzyme Blood Test

North Carolina rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated October 2026.

How much does Biotinidase Enzyme Blood Test cost?

$13.49

Typical negotiated rate. In North Carolina, October 2026.

Insurers have agreed to pay about $13.49 for this service. The price depends on where it is billed: about $13.49 from a physician practice, and about $20.42 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$13.49$10.96 to $15.85
FacilityA hospital or hospital-owned outpatient department$20.42$13.49 to $37.15

How much rates vary

Facilitymedian $20 · 10th to 90th $13 to $78Professionalmedian $13 · 10th to 90th $8 to $24
$5$10$20$50$100facility $20professional $13

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$13.49
Median
$13.49
Typical High
$43.65
Aetna
Setting
Professional
Modifier
None
Typical Low
$11.22
Median
$13.49
Typical High
$15.49
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$6.76
Median
$6.76
Typical High
$7.24
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$2.69
Median
$2.69
Typical High
$2.95
BCBS North Carolina
Setting
Facility
Modifier
None
Typical Low
$28.84
Median
$37.15
Typical High
$74.13
BCBS North Carolina
Setting
Professional
Modifier
None
Typical Low
$7.59
Median
$13.49
Typical High
$13.49
Cigna
Setting
Facility
Modifier
None
Typical Low
$11.75
Median
$37.15
Typical High
$77.62
Cigna
Setting
Professional
Modifier
None
Typical Low
$8.71
Median
$11.48
Typical High
$25.70
Medcost
Setting
Professional
Modifier
None
Typical Low
$14.13
Median
$30.90
Typical High
$102.33
Medcost
Setting
Facility
Modifier
None
Typical Low
$13.18
Median
$13.49
Typical High
$35.48
Medcost
Setting
Professional
Modifier
None
Typical Low
$4.37
Median
$23.99
Typical High
$30.90
United
Setting
Professional
Modifier
None
Typical Low
$7.08
Median
$11.75
Typical High
$22.91

Where North Carolina sits

The same service costs 18.6 times more in Kansas than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

North Carolina· 42nd of 51

$13.49

KS $53.70KY $2.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.