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Biotinidase Enzyme Blood Test

Colorado rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated July 2026.

How much does Biotinidase Enzyme Blood Test cost?

$16.22

Typical negotiated rate. In Colorado, July 2026.

Insurers have agreed to pay about $16.22 for this service. The price depends on where it is billed: about $12.88 from a physician practice, and about $40.74 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$12.88$11.75 to $14.45
FacilityA hospital or hospital-owned outpatient department$40.74$22.39 to $70.79

How much rates vary

Facilitymedian $41 · 10th to 90th $13 to $93Professionalmedian $13 · 10th to 90th $7 to $16
$2$5$10$20$50$100facility $41professional $13

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$10.72
Median
$29.51
Typical High
$97.72
Aetna
Setting
Professional
Modifier
Global
Typical Low
$12.30
Median
$12.88
Typical High
$15.85
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$20.89
Median
$50.12
Typical High
$85.11
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$7.08
Median
$7.08
Typical High
$12.88
Cigna
Setting
Facility
Modifier
Global
Typical Low
$9.77
Median
$11.75
Typical High
$44.67
Cigna
Setting
Professional
Modifier
Global
Typical Low
$8.71
Median
$10.96
Typical High
$20.42
Denver HMP
Setting
Facility
Modifier
Global
Typical Low
$4.68
Median
$16.22
Typical High
$29.51
Kaiser Permanente
Setting
Professional
Modifier
Global
Typical Low
$23.99
Median
$41.69
Typical High
$41.69
Select Health
Setting
Facility
Modifier
Global
Typical Low
$17.78
Median
$30.90
Typical High
$35.48
Select Health
Setting
Professional
Modifier
Global
Typical Low
$11.75
Median
$11.75
Typical High
$16.98
United
Setting
Facility
Modifier
Global
Typical Low
$12.59
Median
$16.98
Typical High
$25.12
United
Setting
Professional
Modifier
Global
Typical Low
$7.08
Median
$10.00
Typical High
$16.98

Where Colorado sits

The same service costs 3.2 times more in Nebraska than in Washington, DC. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 33rd of 51

$16.22

NE $39.81DC $12.59

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.