go back

Biotinidase Enzyme Blood Test

Colorado rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated October 2026.

How much does Biotinidase Enzyme Blood Test cost?

$17.78

Typical negotiated rate. In Colorado, October 2026.

Insurers have agreed to pay about $17.78 for this service. The price depends on where it is billed: about $11.75 from a physician practice, and about $48.98 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$11.75$7.08 to $13.49
FacilityA hospital or hospital-owned outpatient department$48.98$29.51 to $58.88

How much rates vary

Facilitymedian $49 · 10th to 90th $13 to $78Professionalmedian $12 · 10th to 90th $7 to $31
$5$10$20$50$100facility $49professional $12

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$16.22
Median
$29.51
Typical High
$77.62
Aetna
Setting
Professional
Modifier
None
Typical Low
$11.22
Median
$12.88
Typical High
$16.98
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$19.05
Median
$50.12
Typical High
$77.62
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$7.08
Median
$11.48
Typical High
$34.67
Cigna
Setting
Facility
Modifier
None
Typical Low
$9.77
Median
$20.42
Typical High
$51.29
Cigna
Setting
Professional
Modifier
None
Typical Low
$8.71
Median
$12.02
Typical High
$23.99
Denver HMP
Setting
Facility
Modifier
None
Typical Low
$5.25
Median
$16.22
Typical High
$29.51
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$13.49
Median
$24.55
Typical High
$43.65
Select Health
Setting
Facility
Modifier
None
Typical Low
$16.98
Median
$30.90
Typical High
$35.48
Select Health
Setting
Professional
Modifier
None
Typical Low
$11.75
Median
$11.75
Typical High
$16.98
United
Setting
Facility
Modifier
None
Typical Low
$20.42
Median
$20.42
Typical High
$20.42
United
Setting
Professional
Modifier
None
Typical Low
$7.08
Median
$10.00
Typical High
$13.49
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$6.03
Median
$6.46
Typical High
$8.51
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$2.45
Median
$2.57
Typical High
$3.39

Where Colorado sits

The same service costs 18.6 times more in Kansas than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 23rd of 51

$17.78

KS $53.70KY $2.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.