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Biotinidase Enzyme Blood Test

Colorado rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated July 2026.

Facilitymedian $41 · 10th–90th $13$930%10%10th90th$41Professionalmedian $13 · 10th–90th $7$160%20%10th90th$13$2.0$5.0$10.0$20.0$50.0$100.0$200.0

Distribution of negotiated rates across all payers (price axis is log-scale). Facility and professional rates are different services and are charted separately. Need provider-level prices? Contact us.

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$10.72
Median
$29.51
Typical High
$97.72
Aetna
Setting
Professional
Modifier
Global
Typical Low
$12.30
Median
$12.88
Typical High
$15.85
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$20.89
Median
$50.12
Typical High
$85.11
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$7.08
Median
$7.08
Typical High
$12.88
Cigna
Setting
Facility
Modifier
Global
Typical Low
$9.77
Median
$11.75
Typical High
$44.67
Cigna
Setting
Professional
Modifier
Global
Typical Low
$8.71
Median
$10.96
Typical High
$20.42
Denver HMP
Setting
Facility
Modifier
Global
Typical Low
$4.68
Median
$16.22
Typical High
$29.51
Kaiser Permanente
Setting
Professional
Modifier
Global
Typical Low
$23.99
Median
$41.69
Typical High
$41.69
Select Health
Setting
Facility
Modifier
Global
Typical Low
$17.78
Median
$30.90
Typical High
$35.48
Select Health
Setting
Professional
Modifier
Global
Typical Low
$11.75
Median
$11.75
Typical High
$16.98
United
Setting
Facility
Modifier
Global
Typical Low
$12.59
Median
$16.98
Typical High
$25.12
United
Setting
Professional
Modifier
Global
Typical Low
$7.08
Median
$10.00
Typical High
$16.98