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Biotinidase Enzyme Blood Test

Indiana rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated July 2026.

How much does Biotinidase Enzyme Blood Test cost?

$15.85

Typical negotiated rate. In Indiana, July 2026.

Insurers have agreed to pay about $15.85 for this service. The price depends on where it is billed: about $13.80 from a physician practice, and about $16.98 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$13.80$9.55 to $13.80
FacilityA hospital or hospital-owned outpatient department$16.98$16.98 to $33.88

How much rates vary

Facilitymedian $17 · 10th to 90th $14 to $50Professionalmedian $14 · 10th to 90th $8 to $16
$2$5$10$20$50$100facility $17professional $14

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$13.80
Median
$20.89
Typical High
$50.12
Aetna
Setting
Professional
Modifier
Global
Typical Low
$10.72
Median
$13.80
Typical High
$15.85
Ambetter
Setting
Professional
Modifier
Global
Typical Low
$11.75
Median
$11.75
Typical High
$11.75
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$16.98
Median
$16.98
Typical High
$50.12
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$2.88
Median
$8.32
Typical High
$15.49
CareSource
Setting
Facility
Modifier
Global
Typical Low
$20.89
Median
$20.89
Typical High
$20.89
Cigna
Setting
Facility
Modifier
Global
Typical Low
$12.02
Median
$16.98
Typical High
$43.65
Cigna
Setting
Professional
Modifier
Global
Typical Low
$8.51
Median
$12.02
Typical High
$36.31
United
Setting
Facility
Modifier
Global
Typical Low
$10.96
Median
$16.98
Typical High
$19.50
United
Setting
Professional
Modifier
Global
Typical Low
$7.08
Median
$10.96
Typical High
$18.62

Where Indiana sits

The same service costs 3.2 times more in Nebraska than in Washington, DC. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Indiana· 39th of 51

$15.85

NE $39.81DC $12.59

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.