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Biotinidase Enzyme Blood Test

Indiana rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated October 2026.

How much does Biotinidase Enzyme Blood Test cost?

$13.18

Typical negotiated rate. In Indiana, October 2026.

Insurers have agreed to pay about $13.18 for this service. The price depends on where it is billed: about $11.22 from a physician practice, and about $16.98 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$11.22$7.76 to $16.98
FacilityA hospital or hospital-owned outpatient department$16.98$16.60 to $34.67

How much rates vary

Facilitymedian $17 · 10th to 90th $13 to $54Professionalmedian $11 · 10th to 90th $8 to $28
$10$100$1Kfacility $17professional $11

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$13.80
Median
$23.44
Typical High
$61.66
Aetna
Setting
Professional
Modifier
None
Typical Low
$12.59
Median
$13.80
Typical High
$28.18
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$13.18
Median
$16.98
Typical High
$50.12
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$7.76
Median
$9.33
Typical High
$19.95
CareSource
Setting
Facility
Modifier
None
Typical Low
$20.89
Median
$20.89
Typical High
$20.89
Cigna
Setting
Facility
Modifier
None
Typical Low
$10.96
Median
$16.98
Typical High
$56.23
Cigna
Setting
Professional
Modifier
None
Typical Low
$10.72
Median
$19.50
Typical High
$45.71
Physicians Health Plan of Northern Indiana
Setting
Facility
Modifier
None
Typical Low
$30.20
Median
$42.66
Typical High
$2,187.76
Physicians Health Plan of Northern Indiana
Setting
Professional
Modifier
None
Typical Low
$10.96
Median
$13.49
Typical High
$15.14
United
Setting
Professional
Modifier
None
Typical Low
$7.08
Median
$12.30
Typical High
$20.42
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$6.31
Median
$6.92
Typical High
$16.60
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$2.51
Median
$2.75
Typical High
$6.61

Where Indiana sits

The same service costs 18.6 times more in Kansas than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Indiana· 47th of 51

$13.18

KS $53.70KY $2.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.