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Biotinidase Enzyme Blood Test

Pennsylvania rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated July 2026.

Facilitymedian $43 · 10th–90th $14$790%20%10th90th$43Professionalmedian $14 · 10th–90th $13$1050%50%10th90th$14$10.0$50.0$200.0$1.0K$5.0K$20.0K

Distribution of negotiated rates across all payers (price axis is log-scale). Facility and professional rates are different services and are charted separately. Need provider-level prices? Contact us.

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$14.45
Median
$42.66
Typical High
$72.44
Aetna
Setting
Professional
Modifier
Global
Typical Low
$13.18
Median
$14.45
Typical High
$104.71
Capital Blue Cross
Setting
Facility
Modifier
Global
Typical Low
$89.13
Median
$120.23
Typical High
$8,511.38
Capital Blue Cross
Setting
Professional
Modifier
Global
Typical Low
$13.18
Median
$13.18
Typical High
$16.60
Cigna
Setting
Facility
Modifier
Global
Typical Low
$12.02
Median
$25.70
Typical High
$57.54
Cigna
Setting
Professional
Modifier
Global
Typical Low
$9.77
Median
$21.38
Typical High
$40.74
Emblem Health
Setting
Professional
Modifier
Global
Typical Low
$7.94
Median
$16.22
Typical High
$24.55
Geisinger
Setting
Facility
Modifier
Global
Typical Low
$16.98
Median
$16.98
Typical High
$16.98
Geisinger
Setting
Professional
Modifier
Global
Typical Low
$16.60
Median
$19.05
Typical High
$29.51
Highmark BCBS
Setting
Facility
Modifier
Global
Typical Low
$22.91
Median
$33.88
Typical High
$151.36
Highmark BCBS
Setting
Professional
Modifier
Global
Typical Low
$10.00
Median
$10.00
Typical High
$10.00
Martin's Point
Setting
Facility
Modifier
Global
Typical Low
$13.80
Median
$42.66
Typical High
$74.13
Martin's Point
Setting
Professional
Modifier
Global
Typical Low
$13.18
Median
$14.45
Typical High
$60.26
Oscar Health
Setting
Facility
Modifier
Global
Typical Low
$323.59
Median
$331.13
Typical High
$549.54
UPMC Health Plan
Setting
Facility
Modifier
Global
Typical Low
$37.15
Median
$75.86
Typical High
$131.83
UPMC Health Plan
Setting
Professional
Modifier
Global
Typical Low
$14.79
Median
$16.98
Typical High
$23.99
United
Setting
Facility
Modifier
Global
Typical Low
$9.33
Median
$16.98
Typical High
$20.42
United
Setting
Professional
Modifier
Global
Typical Low
$7.59
Median
$13.80
Typical High
$29.51