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Biotinidase Enzyme Blood Test

South Dakota rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated July 2026.

How much does Biotinidase Enzyme Blood Test cost?

$20.42

Typical negotiated rate. In South Dakota, July 2026.

Insurers have agreed to pay about $20.42 for this service. The price depends on where it is billed: about $19.50 from a physician practice, and about $32.36 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$19.50$13.18 to $34.67
FacilityA hospital or hospital-owned outpatient department$32.36$26.92 to $32.36

How much rates vary

Facilitymedian $32 · 10th to 90th $19 to $32Professionalmedian $19 · 10th to 90th $11 to $41
$5$10$20$50$100facility $32professional $19

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$11.75
Median
$19.05
Typical High
$19.05
Aetna
Setting
Professional
Modifier
Global
Typical Low
$11.22
Median
$13.18
Typical High
$15.85
Cigna
Setting
Facility
Modifier
Global
Typical Low
$32.36
Median
$32.36
Typical High
$32.36
Cigna
Setting
Professional
Modifier
Global
Typical Low
$19.50
Median
$32.36
Typical High
$40.74
Medica
Setting
Facility
Modifier
Global
Typical Low
$15.85
Median
$20.89
Typical High
$64.57
Medica
Setting
Professional
Modifier
Global
Typical Low
$4.07
Median
$7.08
Typical High
$16.98
Sanford Health Plan
Setting
Professional
Modifier
Global
Typical Low
$15.85
Median
$34.67
Typical High
$46.77
United
Setting
Facility
Modifier
Global
Typical Low
$20.42
Median
$20.42
Typical High
$20.42
United
Setting
Professional
Modifier
Global
Typical Low
$4.07
Median
$12.02
Typical High
$23.44
Wellmark
Setting
Professional
Modifier
Global
Typical Low
$16.98
Median
$16.98
Typical High
$16.98

Where South Dakota sits

The same service costs 3.2 times more in Nebraska than in Washington, DC. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Dakota· 11th of 51

$20.42

NE $39.81DC $12.59

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.