go back

Biotinidase Enzyme Blood Test

Virginia rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated October 2026.

How much does Biotinidase Enzyme Blood Test cost?

$13.49

Typical negotiated rate. In Virginia, October 2026.

Insurers have agreed to pay about $13.49 for this service. The price depends on where it is billed: about $11.75 from a physician practice, and about $25.12 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$11.75$8.51 to $14.13
FacilityA hospital or hospital-owned outpatient department$25.12$16.98 to $41.69

How much rates vary

Facilitymedian $25 · 10th to 90th $16 to $81Professionalmedian $12 · 10th to 90th $8 to $23
$10$100$1K$10Kfacility $25professional $12

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$12.59
Median
$23.44
Typical High
$43.65
Aetna
Setting
Professional
Modifier
None
Typical Low
$12.59
Median
$15.49
Typical High
$15.85
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$16.98
Median
$16.98
Typical High
$83.18
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$8.32
Median
$10.00
Typical High
$12.88
CareFirst
Setting
Professional
Modifier
None
Typical Low
$12.02
Median
$13.49
Typical High
$23.44
Cigna
Setting
Facility
Modifier
None
Typical Low
$17.38
Median
$37.15
Typical High
$66.07
Cigna
Setting
Professional
Modifier
None
Typical Low
$9.33
Median
$12.59
Typical High
$19.50
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$16.98
Median
$20.42
Typical High
$25.12
Medcost
Setting
Professional
Modifier
None
Typical Low
$14.13
Median
$28.18
Typical High
$33.11
Medcost
Setting
Facility
Modifier
None
Typical Low
$13.80
Median
$15.49
Typical High
$34.67
Medcost
Setting
Professional
Modifier
None
Typical Low
$3.89
Median
$14.45
Typical High
$14.45
Sentara
Setting
Facility
Modifier
None
Typical Low
$15.14
Median
$24.55
Typical High
$10,232.93
Sentara
Setting
Professional
Modifier
None
Typical Low
$15.14
Median
$24.55
Typical High
$10,232.93
United
Setting
Facility
Modifier
None
Typical Low
$20.42
Median
$20.42
Typical High
$20.42
United
Setting
Professional
Modifier
None
Typical Low
$7.08
Median
$10.00
Typical High
$17.78
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$6.31
Median
$7.76
Typical High
$7.94
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$2.51
Median
$3.09
Typical High
$3.16

Where Virginia sits

The same service costs 18.6 times more in Kansas than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Virginia· 43rd of 51

$13.49

KS $53.70KY $2.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.