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Biotinidase Enzyme Blood Test

Ohio rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated October 2026.

How much does Biotinidase Enzyme Blood Test cost?

$13.49

Typical negotiated rate. In Ohio, October 2026.

Insurers have agreed to pay about $13.49 for this service. The price depends on where it is billed: about $10.47 from a physician practice, and about $24.55 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$10.47$8.32 to $15.49
FacilityA hospital or hospital-owned outpatient department$24.55$17.78 to $36.31

How much rates vary

Facilitymedian $25 · 10th to 90th $14 to $51Professionalmedian $10 · 10th to 90th $8 to $25
$5$10$20$50$100facility $25professional $10

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$16.98
Median
$37.15
Typical High
$51.29
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$7.94
Median
$16.22
Typical High
$23.99
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$3.16
Median
$6.46
Typical High
$9.55
Aetna
Setting
Professional
Modifier
None
Typical Low
$13.49
Median
$15.49
Typical High
$43.65
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$6.76
Median
$7.94
Typical High
$21.88
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$2.69
Median
$3.16
Typical High
$8.71
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$13.80
Median
$19.50
Typical High
$30.90
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$8.32
Median
$8.91
Typical High
$20.89
CareSource
Setting
Facility
Modifier
None
Typical Low
$11.48
Median
$11.48
Typical High
$19.50
CareSource
Setting
Professional
Modifier
None
Typical Low
$22.91
Median
$22.91
Typical High
$22.91
Cigna
Setting
Facility
Modifier
None
Typical Low
$10.96
Median
$20.42
Typical High
$56.23
Cigna
Setting
Professional
Modifier
None
Typical Low
$8.51
Median
$10.72
Typical High
$23.99
Medical Mutual of Ohio
Setting
Facility
Modifier
None
Typical Low
$11.22
Median
$22.39
Typical High
$64.57
Medical Mutual of Ohio
Setting
Professional
Modifier
None
Typical Low
$8.51
Median
$10.72
Typical High
$23.44
Molina
Setting
Professional
Modifier
None
Typical Low
$9.33
Median
$11.75
Typical High
$20.42
SummaCare
Setting
Professional
Modifier
None
Typical Low
$10.96
Median
$14.45
Typical High
$20.42
United
Setting
Facility
Modifier
None
Typical Low
$6.03
Median
$15.14
Typical High
$25.12
United
Setting
Professional
Modifier
None
Typical Low
$7.08
Median
$11.75
Typical High
$23.99

Where Ohio sits

The same service costs 18.6 times more in Kansas than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Ohio· 43rd of 51

$13.49

KS $53.70KY $2.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.