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Biotinidase Enzyme Blood Test

Alabama rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated October 2026.

How much does Biotinidase Enzyme Blood Test cost?

$17.78

Typical negotiated rate. In Alabama, October 2026.

Insurers have agreed to pay about $17.78 for this service. The price depends on where it is billed: about $13.80 from a physician practice, and about $17.78 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 4 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$13.80$8.71 to $19.50
FacilityA hospital or hospital-owned outpatient department$17.78$17.78 to $17.78

How much rates vary

Facilitymedian $18 · 10th to 90th $18 to $18Professionalmedian $14 · 10th to 90th $7 to $21
$10$20$50$100facility $18professional $14

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$19.50
Median
$19.50
Typical High
$25.70
Aetna
Setting
Professional
Modifier
None
Typical Low
$13.80
Median
$19.50
Typical High
$19.50
BCBS Alabama
Setting
Facility
Modifier
None
Typical Low
$17.78
Median
$17.78
Typical High
$17.78
BCBS Alabama
Setting
Professional
Modifier
21 + 22 · Increased work + 24 · Unrelated visit after surgery + 31
Typical Low
$11.75
Median
$14.13
Typical High
$17.38
Cigna
Setting
Facility
Modifier
None
Typical Low
$13.80
Median
$14.13
Typical High
$53.70
Cigna
Setting
Professional
Modifier
None
Typical Low
$8.71
Median
$10.47
Typical High
$95.50
United
Setting
Facility
Modifier
None
Typical Low
$6.03
Median
$15.14
Typical High
$16.98
United
Setting
Professional
Modifier
None
Typical Low
$7.08
Median
$9.55
Typical High
$13.80
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$7.59
Median
$9.77
Typical High
$9.77
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$3.02
Median
$3.89
Typical High
$3.89

Where Alabama sits

The same service costs 18.6 times more in Kansas than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Alabama· 22nd of 51

$17.78

KS $53.70KY $2.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.