go back

Biotinidase Enzyme Blood Test

South Carolina rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated October 2026.

How much does Biotinidase Enzyme Blood Test cost?

$25.70

Typical negotiated rate. In South Carolina, October 2026.

Insurers have agreed to pay about $25.70 for this service. The price depends on where it is billed: about $25.12 from a physician practice, and about $48.98 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$25.12$16.98 to $37.15
FacilityA hospital or hospital-owned outpatient department$48.98$35.48 to $85.11

How much rates vary

Facilitymedian $49 · 10th to 90th $18 to $105Professionalmedian $25 · 10th to 90th $11 to $37
$10$20$50$100facility $49professional $25

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$13.18
Median
$13.18
Typical High
$13.18
Aetna
Setting
Professional
Modifier
None
Typical Low
$13.18
Median
$13.18
Typical High
$13.49
BCBS South Carolina
Setting
Facility
Modifier
None
Typical Low
$30.20
Median
$54.95
Typical High
$102.33
BCBS South Carolina
Setting
Professional
Modifier
None
Typical Low
$16.98
Median
$25.70
Typical High
$37.15
Cigna
Setting
Facility
Modifier
None
Typical Low
$31.62
Median
$42.66
Typical High
$104.71
Cigna
Setting
Professional
Modifier
None
Typical Low
$8.51
Median
$10.96
Typical High
$21.38
Medcost
Setting
Facility
Modifier
None
Typical Low
$12.30
Median
$16.98
Typical High
$23.99
Medcost
Setting
Professional
Modifier
None
Typical Low
$19.05
Median
$25.12
Typical High
$26.92
United
Setting
Facility
Modifier
None
Typical Low
$15.14
Median
$15.14
Typical High
$20.42
United
Setting
Professional
Modifier
None
Typical Low
$7.08
Median
$10.23
Typical High
$20.89
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$6.61
Median
$6.61
Typical High
$6.76
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$2.63
Median
$2.63
Typical High
$2.69

Where South Carolina sits

The same service costs 18.6 times more in Kansas than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Carolina· 5th of 51

$25.70

KS $53.70KY $2.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.