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Biotinidase Enzyme Blood Test

South Carolina rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated July 2026.

How much does Biotinidase Enzyme Blood Test cost?

$14.45

Typical negotiated rate. In South Carolina, July 2026.

Insurers have agreed to pay about $14.45 for this service. The price depends on where it is billed: about $13.18 from a physician practice, and about $41.69 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$13.18$13.18 to $14.79
FacilityA hospital or hospital-owned outpatient department$41.69$16.98 to $70.79

How much rates vary

Facilitymedian $42 · 10th to 90th $13 to $91Professionalmedian $13 · 10th to 90th $13 to $25
$1$2$5$10$20$50$100facility $42professional $13

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$13.18
Median
$41.69
Typical High
$79.43
Aetna
Setting
Professional
Modifier
Global
Typical Low
$13.18
Median
$13.18
Typical High
$14.79
BCBS
Setting
Facility
Modifier
Global
Typical Low
$10.72
Median
$58.88
Typical High
$104.71
BCBS
Setting
Professional
Modifier
Global
Typical Low
$17.38
Median
$25.70
Typical High
$37.15
Cigna
Setting
Facility
Modifier
Global
Typical Low
$31.62
Median
$54.95
Typical High
$138.04
Cigna
Setting
Professional
Modifier
Global
Typical Low
$8.51
Median
$10.96
Typical High
$21.88
Medcost
Setting
Facility
Modifier
Global
Typical Low
$12.30
Median
$17.78
Typical High
$35.48
United
Setting
Facility
Modifier
Global
Typical Low
$9.33
Median
$16.98
Typical High
$20.89
United
Setting
Professional
Modifier
Global
Typical Low
$7.08
Median
$10.23
Typical High
$23.44

Where South Carolina sits

The same service costs 3.2 times more in Nebraska than in Washington, DC. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Carolina· 44th of 51

$14.45

NE $39.81DC $12.59

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.