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Biotinidase Enzyme Blood Test

Florida rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated October 2026.

How much does Biotinidase Enzyme Blood Test cost?

$16.60

Typical negotiated rate. In Florida, October 2026.

Insurers have agreed to pay about $16.60 for this service. The price depends on where it is billed: about $13.80 from a physician practice, and about $30.90 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$13.80$10.00 to $20.42
FacilityA hospital or hospital-owned outpatient department$30.90$17.38 to $30.90

How much rates vary

Facilitymedian $31 · 10th to 90th $15 to $36Professionalmedian $14 · 10th to 90th $7 to $35
$5$10$20$50facility $31professional $14

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$13.80
Median
$15.85
Typical High
$46.77
Aetna
Setting
Professional
Modifier
None
Typical Low
$12.59
Median
$14.45
Typical High
$15.85
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$6.61
Median
$7.24
Typical High
$7.76
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$2.63
Median
$2.95
Typical High
$3.16
Ambetter
Setting
Professional
Modifier
None
Typical Low
$10.00
Median
$10.23
Typical High
$10.23
AvMed
Setting
Facility
Modifier
None
Typical Low
$13.49
Median
$16.98
Typical High
$20.42
AvMed
Setting
Professional
Modifier
None
Typical Low
$13.49
Median
$16.98
Typical High
$23.99
Cigna
Setting
Facility
Modifier
None
Typical Low
$11.75
Median
$20.89
Typical High
$67.61
Cigna
Setting
Professional
Modifier
None
Typical Low
$8.91
Median
$17.38
Typical High
$33.88
Florida Blue
Setting
Facility
Modifier
None
Typical Low
$17.38
Median
$30.90
Typical High
$30.90
Florida Blue
Setting
Professional
Modifier
None
Typical Low
$10.00
Median
$13.18
Typical High
$23.44
Molina
Setting
Professional
Modifier
None
Typical Low
$1.32
Median
$5.25
Typical High
$11.75
United
Setting
Facility
Modifier
None
Typical Low
$16.98
Median
$16.98
Typical High
$16.98
United
Setting
Professional
Modifier
None
Typical Low
$7.08
Median
$10.23
Typical High
$54.95
Wellpoint
Setting
Professional
Modifier
None
Typical Low
$6.61
Median
$6.61
Typical High
$16.98

Where Florida sits

The same service costs 18.6 times more in Kansas than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Florida· 31st of 51

$16.60

KS $53.70KY $2.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.