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Biotinidase Enzyme Blood Test

Iowa rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated October 2026.

How much does Biotinidase Enzyme Blood Test cost?

$20.42

Typical negotiated rate. In Iowa, October 2026.

Insurers have agreed to pay about $20.42 for this service. The price depends on where it is billed: about $16.98 from a physician practice, and about $28.84 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$16.98$13.18 to $32.36
FacilityA hospital or hospital-owned outpatient department$28.84$20.42 to $44.67

How much rates vary

Facilitymedian $29 · 10th to 90th $17 to $52Professionalmedian $17 · 10th to 90th $10 to $43
$10$20$50$100facility $29professional $17

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$13.18
Median
$32.36
Typical High
$47.86
Aetna
Setting
Professional
Modifier
None
Typical Low
$11.22
Median
$13.18
Typical High
$20.42
Cigna
Setting
Professional
Modifier
None
Typical Low
$19.50
Median
$32.36
Typical High
$40.74
Hally Health
Setting
Professional
Modifier
None
Typical Low
$16.98
Median
$29.51
Typical High
$44.67
Medica
Setting
Facility
Modifier
None
Typical Low
$20.42
Median
$30.20
Typical High
$52.48
Medica
Setting
Professional
Modifier
None
Typical Low
$10.00
Median
$17.38
Typical High
$43.65
Midlands
Setting
Professional
Modifier
None
Typical Low
$20.89
Median
$20.89
Typical High
$22.39
Midlands
Setting
Facility
Modifier
None
Typical Low
$20.89
Median
$20.89
Typical High
$20.89
United
Setting
Facility
Modifier
None
Typical Low
$16.98
Median
$16.98
Typical High
$43.65
United
Setting
Professional
Modifier
None
Typical Low
$10.00
Median
$14.79
Typical High
$23.44
Wellmark
Setting
Professional
Modifier
None
Typical Low
$13.18
Median
$16.98
Typical High
$16.98

Where Iowa sits

The same service costs 18.6 times more in Kansas than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Iowa· 13th of 51

$20.42

KS $53.70KY $2.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.