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Biotinidase Enzyme Blood Test

Missouri rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated July 2026.

How much does Biotinidase Enzyme Blood Test cost?

$21.88

Typical negotiated rate. In Missouri, July 2026.

Insurers have agreed to pay about $21.88 for this service. The price depends on where it is billed: about $16.22 from a physician practice, and about $28.18 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$16.22$11.75 to $26.92
FacilityA hospital or hospital-owned outpatient department$28.18$16.98 to $42.66

How much rates vary

Facilitymedian $28 · 10th to 90th $14 to $63Professionalmedian $16 · 10th to 90th $8 to $40
$5$10$20$50$100facility $28professional $16

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$14.45
Median
$29.51
Typical High
$63.10
Aetna
Setting
Professional
Modifier
Global
Typical Low
$14.45
Median
$16.22
Typical High
$39.81
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$16.98
Median
$16.98
Typical High
$58.88
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$8.32
Median
$14.13
Typical High
$43.65
BCBS
Setting
Facility
Modifier
Global
Typical Low
$31.62
Median
$33.11
Typical High
$38.02
Cigna
Setting
Facility
Modifier
Global
Typical Low
$22.39
Median
$32.36
Typical High
$93.33
Cigna
Setting
Professional
Modifier
Global
Typical Low
$8.91
Median
$16.22
Typical High
$43.65
Medica
Setting
Facility
Modifier
Global
Typical Low
$15.14
Median
$29.51
Typical High
$93.33
Medica
Setting
Professional
Modifier
Global
Typical Low
$7.08
Median
$10.00
Typical High
$20.42
United
Setting
Facility
Modifier
Global
Typical Low
$9.55
Median
$16.98
Typical High
$22.39
United
Setting
Professional
Modifier
Global
Typical Low
$7.08
Median
$12.59
Typical High
$22.91

Where Missouri sits

The same service costs 3.2 times more in Nebraska than in Washington, DC. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Missouri· 8th of 51

$21.88

NE $39.81DC $12.59

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.