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Biotinidase Enzyme Blood Test

Missouri rates for HCPCS 82261

A blood test that measures the activity of biotinidase, an enzyme the body needs to recycle the vitamin biotin. It is used mainly in newborn screening to detect biotinidase deficiency, a rare inherited condition.

Rates data updated October 2026.

How much does Biotinidase Enzyme Blood Test cost?

$20.42

Typical negotiated rate. In Missouri, October 2026.

Insurers have agreed to pay about $20.42 for this service. The price depends on where it is billed: about $16.22 from a physician practice, and about $30.90 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$16.22$10.00 to $34.67
FacilityA hospital or hospital-owned outpatient department$30.90$22.39 to $57.54

How much rates vary

Facilitymedian $31 · 10th to 90th $16 to $93Professionalmedian $16 · 10th to 90th $8 to $35
$10$20$50$100facility $31professional $16

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$14.45
Median
$23.44
Typical High
$36.31
Aetna
Setting
Professional
Modifier
None
Typical Low
$14.45
Median
$14.45
Typical High
$16.22
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$16.98
Median
$16.98
Typical High
$77.62
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$8.32
Median
$25.12
Typical High
$42.66
BCBS Kansas City
Setting
Facility
Modifier
None
Typical Low
$25.70
Median
$33.11
Typical High
$63.10
Cigna
Setting
Facility
Modifier
None
Typical Low
$22.39
Median
$37.15
Typical High
$95.50
Cigna
Setting
Professional
Modifier
None
Typical Low
$9.77
Median
$19.05
Typical High
$35.48
Medica
Setting
Facility
Modifier
None
Typical Low
$15.14
Median
$29.51
Typical High
$93.33
Medica
Setting
Professional
Modifier
None
Typical Low
$7.08
Median
$12.02
Typical High
$21.38
United
Setting
Facility
Modifier
None
Typical Low
$15.14
Median
$15.14
Typical High
$15.14
United
Setting
Professional
Modifier
None
Typical Low
$7.08
Median
$12.59
Typical High
$22.91
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$7.24
Median
$7.24
Typical High
$9.77
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$2.88
Median
$2.88
Typical High
$3.89

Where Missouri sits

The same service costs 18.6 times more in Kansas than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Missouri· 11th of 51

$20.42

KS $53.70KY $2.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.