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JAK2 V617F Gene Change Test

Nationwide rates for HCPCS 81270

Looks in a blood or bone-marrow sample for one specific change in the JAK2 gene, known as V617F, which drives the marrow to overproduce blood cells. Finding it supports the diagnosis of a myeloproliferative disorder such as polycythemia vera, essential thrombocythemia or myelofibrosis. The change is picked up during life in the blood-forming cells rather than inherited.

Rates data updated July 2026.

Facilitymedian $174 · 10th–90th $78$5010%10%10th90th$174Professionalmedian $79 · 10th–90th $52$2240%20%10th90th$79$0.1$1.0$10.0$100.0$1.0K$10.0K$100.0K

Distribution of negotiated rates across all payers (price axis is log-scale). Facility and professional rates are different services and are charted separately. Need provider-level prices? Contact us.

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$75.86
Median
$181.97
Typical High
$537.03
Aetna
Setting
Professional
Modifier
Global
Typical Low
$60.26
Median
$77.62
Typical High
$275.42
BCBS
Setting
Facility
Modifier
Global
Typical Low
$91.20
Median
$134.90
Typical High
$389.05
BCBS
Setting
Professional
Modifier
Global
Typical Low
$43.65
Median
$56.23
Typical High
$169.82
Cigna
Setting
Facility
Modifier
Global
Typical Low
$79.43
Median
$194.98
Typical High
$416.87
Cigna
Setting
Professional
Modifier
Global
Typical Low
$47.86
Median
$109.65
Typical High
$218.78
United
Setting
Facility
Modifier
Global
Typical Low
$52.48
Median
$91.20
Typical High
$138.04
United
Setting
Professional
Modifier
Global
Typical Low
$38.90
Median
$63.10
Typical High
$186.21