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JAK2 V617F Gene Change Test

Colorado rates for HCPCS 81270

Looks in a blood or bone-marrow sample for one specific change in the JAK2 gene, known as V617F, which drives the marrow to overproduce blood cells. Finding it supports the diagnosis of a myeloproliferative disorder such as polycythemia vera, essential thrombocythemia or myelofibrosis. The change is picked up during life in the blood-forming cells rather than inherited.

Rates data updated October 2026.

How much does JAK2 V617F Gene Change Test cost?

$123

Typical negotiated rate. In Colorado, October 2026.

Insurers have agreed to pay about $123 for this service. The price depends on where it is billed: about $56.23 from a physician practice, and about $263 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$56.23$38.90 to $120
FacilityA hospital or hospital-owned outpatient department$263$166 to $316

How much rates vary

Facilitymedian $263 · 10th to 90th $71 to $417Professionalmedian $56 · 10th to 90th $39 to $191
$50$100$200$500facility $263professional $56

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$69.18
Median
$158.49
Typical High
$426.58
Aetna
Setting
Professional
Modifier
None
Typical Low
$61.66
Median
$69.18
Typical High
$128.82
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$97.72
Median
$275.42
Typical High
$416.87
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$38.90
Median
$38.90
Typical High
$204.17
Cigna
Setting
Facility
Modifier
None
Typical Low
$53.70
Median
$109.65
Typical High
$288.40
Cigna
Setting
Professional
Modifier
None
Typical Low
$43.65
Median
$56.23
Typical High
$131.83
Denver HMP
Setting
Facility
Modifier
None
Typical Low
$69.18
Median
$89.13
Typical High
$154.88
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$91.20
Median
$128.82
Typical High
$234.42
Select Health
Setting
Facility
Modifier
None
Typical Low
$91.20
Median
$169.82
Typical High
$190.55
Select Health
Setting
Professional
Modifier
None
Typical Low
$64.57
Median
$91.20
Typical High
$138.04
United
Setting
Facility
Modifier
None
Typical Low
$109.65
Median
$109.65
Typical High
$109.65
United
Setting
Professional
Modifier
None
Typical Low
$38.90
Median
$52.48
Typical High
$67.61
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$34.67
Median
$34.67
Typical High
$48.98
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$13.80
Median
$13.80
Typical High
$19.50

Where Colorado sits

The same service costs 3.2 times more in Alaska than in Connecticut. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 7th of 51

$123

AK $204CT $63.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.