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JAK2 V617F Gene Change Test

Colorado rates for HCPCS 81270

Looks in a blood or bone-marrow sample for one specific change in the JAK2 gene, known as V617F, which drives the marrow to overproduce blood cells. Finding it supports the diagnosis of a myeloproliferative disorder such as polycythemia vera, essential thrombocythemia or myelofibrosis. The change is picked up during life in the blood-forming cells rather than inherited.

Rates data updated July 2026.

How much does JAK2 V617F Gene Change Test cost?

$115

Typical negotiated rate. In Colorado, July 2026.

Insurers have agreed to pay about $115 for this service. The price depends on where it is billed: about $69.18 from a physician practice, and about $224 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$69.18$57.54 to $87.10
FacilityA hospital or hospital-owned outpatient department$224$123 to $363

How much rates vary

Facilitymedian $224 · 10th to 90th $69 to $427Professionalmedian $69 · 10th to 90th $39 to $186
$50$100$200$500facility $224professional $69

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$69.18
Median
$190.55
Typical High
$426.58
Aetna
Setting
Professional
Modifier
Global
Typical Low
$61.66
Median
$74.13
Typical High
$186.21
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$114.82
Median
$275.42
Typical High
$467.74
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$38.90
Median
$38.90
Typical High
$91.20
Cigna
Setting
Facility
Modifier
Global
Typical Low
$53.70
Median
$60.26
Typical High
$239.88
Cigna
Setting
Professional
Modifier
Global
Typical Low
$46.77
Median
$52.48
Typical High
$134.90
Denver HMP
Setting
Facility
Modifier
Global
Typical Low
$69.18
Median
$91.20
Typical High
$144.54
Kaiser Permanente
Setting
Professional
Modifier
Global
Typical Low
$128.82
Median
$128.82
Typical High
$575.44
Select Health
Setting
Facility
Modifier
Global
Typical Low
$95.50
Median
$169.82
Typical High
$190.55
Select Health
Setting
Professional
Modifier
Global
Typical Low
$64.57
Median
$91.20
Typical High
$138.04
United
Setting
Facility
Modifier
Global
Typical Low
$91.20
Median
$100.00
Typical High
$151.36
United
Setting
Professional
Modifier
Global
Typical Low
$38.90
Median
$52.48
Typical High
$100.00

Where Colorado sits

The same service costs 3.1 times more in Nebraska than in Vermont. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 13th of 51

$115

NE $204VT $66.07

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.