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JAK2 V617F Gene Change Test

Missouri rates for HCPCS 81270

Looks in a blood or bone-marrow sample for one specific change in the JAK2 gene, known as V617F, which drives the marrow to overproduce blood cells. Finding it supports the diagnosis of a myeloproliferative disorder such as polycythemia vera, essential thrombocythemia or myelofibrosis. The change is picked up during life in the blood-forming cells rather than inherited.

Rates data updated October 2026.

How much does JAK2 V617F Gene Change Test cost?

$89.13

Typical negotiated rate. In Missouri, October 2026.

Insurers have agreed to pay about $89.13 for this service. The price depends on where it is billed: about $79.43 from a physician practice, and about $158 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$79.43$56.23 to $148
FacilityA hospital or hospital-owned outpatient department$158$91.20 to $234

How much rates vary

Facilitymedian $158 · 10th to 90th $83 to $437Professionalmedian $79 · 10th to 90th $46 to $309
$20$50$100$200$500facility $158professional $79

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$79.43
Median
$112.20
Typical High
$169.82
Aetna
Setting
Professional
Modifier
None
Typical Low
$67.61
Median
$79.43
Typical High
$104.71
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$91.20
Median
$91.20
Typical High
$426.58
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$56.23
Median
$83.18
Typical High
$169.82
BCBS Kansas City
Setting
Professional
Modifier
None
Typical Low
$64.57
Median
$125.89
Typical High
$173.78
Cigna
Setting
Facility
Modifier
None
Typical Low
$87.10
Median
$204.17
Typical High
$524.81
Cigna
Setting
Professional
Modifier
None
Typical Low
$43.65
Median
$104.71
Typical High
$158.49
Medica
Setting
Facility
Modifier
None
Typical Low
$83.18
Median
$158.49
Typical High
$436.52
Medica
Setting
Professional
Modifier
None
Typical Low
$45.71
Median
$102.33
Typical High
$457.09
United
Setting
Facility
Modifier
None
Typical Low
$83.18
Median
$83.18
Typical High
$83.18
United
Setting
Professional
Modifier
None
Typical Low
$38.90
Median
$54.95
Typical High
$123.03
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$38.90
Median
$39.81
Typical High
$52.48
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$15.49
Median
$15.85
Typical High
$20.89

Where Missouri sits

The same service costs 3.2 times more in Alaska than in Connecticut. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Missouri· 29th of 51

$89.13

AK $204CT $63.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.