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JAK2 V617F Gene Change Test

Maryland rates for HCPCS 81270

Looks in a blood or bone-marrow sample for one specific change in the JAK2 gene, known as V617F, which drives the marrow to overproduce blood cells. Finding it supports the diagnosis of a myeloproliferative disorder such as polycythemia vera, essential thrombocythemia or myelofibrosis. The change is picked up during life in the blood-forming cells rather than inherited.

Rates data updated October 2026.

How much does JAK2 V617F Gene Change Test cost?

$69.18

Typical negotiated rate. In Maryland, October 2026.

Insurers have agreed to pay about $69.18 for this service. Most negotiated rates run $60.26 to $75.86.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Facilitymedian $110 · 10th to 90th $68 to $135Professionalmedian $68 · 10th to 90th $50 to $98
$50$100$200facility $110professional $68

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$67.61
Median
$109.65
Typical High
$134.90
Aetna
Setting
Professional
Modifier
None
Typical Low
$67.61
Median
$69.18
Typical High
$75.86
CareFirst
Setting
Professional
Modifier
None
Typical Low
$66.07
Median
$74.13
Typical High
$74.13
Cigna
Setting
Professional
Modifier
None
Typical Low
$47.86
Median
$72.44
Typical High
$263.03
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$91.20
Median
$109.65
Typical High
$138.04
United
Setting
Professional
Modifier
None
Typical Low
$41.69
Median
$52.48
Typical High
$85.11
Wellpoint
Setting
Professional
Modifier
None
Typical Low
$89.13
Median
$89.13
Typical High
$89.13
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$33.88
Median
$34.67
Typical High
$37.15
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$13.49
Median
$13.80
Typical High
$14.79

Where Maryland sits

The same service costs 3.2 times more in Alaska than in Connecticut. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Maryland· 48th of 51

$69.18

AK $204CT $63.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.