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JAK2 V617F Gene Change Test

South Carolina rates for HCPCS 81270

Looks in a blood or bone-marrow sample for one specific change in the JAK2 gene, known as V617F, which drives the marrow to overproduce blood cells. Finding it supports the diagnosis of a myeloproliferative disorder such as polycythemia vera, essential thrombocythemia or myelofibrosis. The change is picked up during life in the blood-forming cells rather than inherited.

Rates data updated October 2026.

How much does JAK2 V617F Gene Change Test cost?

$91.20

Typical negotiated rate. In South Carolina, October 2026.

Insurers have agreed to pay about $91.20 for this service. The price depends on where it is billed: about $91.20 from a physician practice, and about $191 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$91.20$70.79 to $91.20
FacilityA hospital or hospital-owned outpatient department$191$110 to $389

How much rates vary

Facilitymedian $191 · 10th to 90th $71 to $562Professionalmedian $91 · 10th to 90th $55 to $126
$50$100$200$500facility $191professional $91

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$70.79
Median
$70.79
Typical High
$147.91
Aetna
Setting
Professional
Modifier
None
Typical Low
$70.79
Median
$70.79
Typical High
$87.10
BCBS South Carolina
Setting
Facility
Modifier
None
Typical Low
$199.53
Median
$363.08
Typical High
$562.34
BCBS South Carolina
Setting
Professional
Modifier
None
Typical Low
$91.20
Median
$91.20
Typical High
$125.89
Cigna
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$234.42
Typical High
$562.34
Cigna
Setting
Professional
Modifier
None
Typical Low
$45.71
Median
$57.54
Typical High
$95.50
Medcost
Setting
Facility
Modifier
None
Typical Low
$70.79
Median
$85.11
Typical High
$263.03
Medcost
Setting
Professional
Modifier
None
Typical Low
$109.65
Median
$125.89
Typical High
$128.82
United
Setting
Facility
Modifier
None
Typical Low
$83.18
Median
$83.18
Typical High
$109.65
United
Setting
Professional
Modifier
None
Typical Low
$38.90
Median
$63.10
Typical High
$109.65
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$35.48
Median
$35.48
Typical High
$36.31
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$14.45
Median
$14.45
Typical High
$14.79
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$63.10
Median
$63.10
Typical High
$85.11

Where South Carolina sits

The same service costs 3.2 times more in Alaska than in Connecticut. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Carolina· 24th of 51

$91.20

AK $204CT $63.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.