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JAK2 V617F Gene Change Test

New Jersey rates for HCPCS 81270

Looks in a blood or bone-marrow sample for one specific change in the JAK2 gene, known as V617F, which drives the marrow to overproduce blood cells. Finding it supports the diagnosis of a myeloproliferative disorder such as polycythemia vera, essential thrombocythemia or myelofibrosis. The change is picked up during life in the blood-forming cells rather than inherited.

Rates data updated July 2026.

Facilitymedian $282 · 10th–90th $91$1,2590%10%10th90th$282Professionalmedian $68 · 10th–90th $58$1050%20%40%10th90th$68$50.0$200.0$1.0K$5.0K$20.0K$100.0K

Distribution of negotiated rates across all payers (price axis is log-scale). Facility and professional rates are different services and are charted separately. Need provider-level prices? Contact us.

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$97.72
Median
$295.12
Typical High
$575.44
Aetna
Setting
Professional
Modifier
Global
Typical Low
$57.54
Median
$70.79
Typical High
$104.71
AmeriHealth
Setting
Facility
Modifier
Global
Typical Low
$131.83
Median
$407.38
Typical High
$5,495.41
Cigna
Setting
Facility
Modifier
Global
Typical Low
$104.71
Median
$204.17
Typical High
$416.87
Cigna
Setting
Professional
Modifier
Global
Typical Low
$54.95
Median
$77.62
Typical High
$186.21
Emblem Health
Setting
Professional
Modifier
Global
Typical Low
$64.57
Median
$104.71
Typical High
$173.78
Horizon BCBS
Setting
Facility
Modifier
Global
Typical Low
$91.20
Median
$10,471.29
Typical High
$23,988.33
Horizon BCBS
Setting
Professional
Modifier
Global
Typical Low
$72.44
Median
$72.44
Typical High
$91.20
United
Setting
Facility
Modifier
Global
Typical Low
$42.66
Median
$91.20
Typical High
$199.53
United
Setting
Professional
Modifier
Global
Typical Low
$38.90
Median
$54.95
Typical High
$125.89