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SEPT9 Methylation Blood Test for Colon Cancer

South Dakota rates for HCPCS 81327

A blood test that looks for a chemical change called methylation affecting the SEPT9 gene. This change is frequently present when colorectal cancer is developing, so finding it in blood flags the need for a closer look at the bowel. It is offered as a colorectal cancer screening option for people who will not undergo other forms of screening.

Rates data updated July 2026.

How much does SEPT9 Methylation Blood Test for Colon Cancer cost?

$288

Typical negotiated rate. In South Dakota, July 2026.

Insurers have agreed to pay about $288 for this service. The price depends on where it is billed: about $219 from a physician practice, and about $372 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$219$151 to $447
FacilityA hospital or hospital-owned outpatient department$372$372 to $372

How much rates vary

Facilitymedian $372 · 10th to 90th $219 to $372Professionalmedian $219 · 10th to 90th $129 to $468
$50.0$100.0$200.0$500.0$1.0Kfacility $372professional $219

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$134.90
Median
$218.78
Typical High
$218.78
Aetna
Setting
Professional
Modifier
Global
Typical Low
$128.82
Median
$151.36
Typical High
$181.97
Cigna
Setting
Facility
Modifier
Global
Typical Low
$371.54
Median
$371.54
Typical High
$371.54
Cigna
Setting
Professional
Modifier
Global
Typical Low
$229.09
Median
$371.54
Typical High
$457.09
Medica
Setting
Facility
Modifier
Global
Typical Low
$181.97
Median
$218.78
Typical High
$354.81
Medica
Setting
Professional
Modifier
Global
Typical Low
$42.66
Median
$81.28
Typical High
$954.99
Sanford Health Plan
Setting
Professional
Modifier
Global
Typical Low
$275.42
Median
$446.68
Typical High
$524.81
United
Setting
Professional
Modifier
Global
Typical Low
$42.66
Median
$114.82
Typical High
$218.78
Wellmark
Setting
Professional
Modifier
Global
Typical Low
$190.55
Median
$190.55
Typical High
$190.55

Where South Dakota sits

The same service costs 6.9 times more in Alaska than in California. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

South Dakota $288 · 3rd of 51
AK $437CA $63.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.