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SEPT9 Methylation Blood Test for Colon Cancer

Missouri rates for HCPCS 81327

A blood test that looks for a chemical change called methylation affecting the SEPT9 gene. This change is frequently present when colorectal cancer is developing, so finding it in blood flags the need for a closer look at the bowel. It is offered as a colorectal cancer screening option for people who will not undergo other forms of screening.

Rates data updated October 2026.

How much does SEPT9 Methylation Blood Test for Colon Cancer cost?

$162

Typical negotiated rate. In Missouri, October 2026.

Insurers have agreed to pay about $162 for this service. The price depends on where it is billed: about $138 from a physician practice, and about $331 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$138$50.12 to $240
FacilityA hospital or hospital-owned outpatient department$331$174 to $427

How much rates vary

Facilitymedian $331 · 10th to 90th $117 to $912Professionalmedian $138 · 10th to 90th $50 to $501
$50$100$200$500$1Kfacility $331professional $138

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$162.18
Median
$245.47
Typical High
$354.81
Aetna
Setting
Professional
Modifier
None
Typical Low
$141.25
Median
$165.96
Typical High
$218.78
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$50.12
Median
$109.65
Typical High
$346.74
BCBS Kansas City
Setting
Facility
Modifier
None
Typical Low
$117.49
Median
$120.23
Typical High
$229.09
BCBS Kansas City
Setting
Professional
Modifier
None
Typical Low
$83.18
Median
$134.90
Typical High
$363.08
Cigna
Setting
Facility
Modifier
None
Typical Low
$125.89
Median
$371.54
Typical High
$524.81
Cigna
Setting
Professional
Modifier
None
Typical Low
$38.02
Median
$102.33
Typical High
$223.87
Medica
Setting
Facility
Modifier
None
Typical Low
$72.44
Median
$229.09
Typical High
$912.01
Medica
Setting
Professional
Modifier
None
Typical Low
$50.12
Median
$190.55
Typical High
$954.99
United
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$173.78
Typical High
$173.78
United
Setting
Professional
Modifier
None
Typical Low
$50.12
Median
$114.82
Typical High
$251.19
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$81.28
Median
$83.18
Typical High
$109.65
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$32.36
Median
$33.11
Typical High
$44.67

Where Missouri sits

The same service costs 5.4 times more in Texas than in Ohio. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Missouri· 22nd of 51

$162

TX $468OH $87.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.