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SEPT9 Methylation Blood Test for Colon Cancer

Missouri rates for HCPCS 81327

A blood test that looks for a chemical change called methylation affecting the SEPT9 gene. This change is frequently present when colorectal cancer is developing, so finding it in blood flags the need for a closer look at the bowel. It is offered as a colorectal cancer screening option for people who will not undergo other forms of screening.

Rates data updated July 2026.

How much does SEPT9 Methylation Blood Test for Colon Cancer cost?

$170

Typical negotiated rate. In Missouri, July 2026.

Insurers have agreed to pay about $170 for this service. The price depends on where it is billed: about $162 from a physician practice, and about $269 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$162$50.12 to $209
FacilityA hospital or hospital-owned outpatient department$269$191 to $331

How much rates vary

Facilitymedian $269 · 10th to 90th $162 to $407Professionalmedian $162 · 10th to 90th $33 to $331
$10.0$20.0$50.0$100.0$200.0$500.0$1.0Kfacility $269professional $162

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$186.21
Median
$323.59
Typical High
$446.68
Aetna
Setting
Professional
Modifier
Global
Typical Low
$147.91
Median
$165.96
Typical High
$380.19
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$33.11
Median
$51.29
Typical High
$302.00
BCBS
Setting
Facility
Modifier
Global
Typical Low
$117.49
Median
$120.23
Typical High
$218.78
BCBS
Setting
Professional
Modifier
Global
Typical Low
$83.18
Median
$134.90
Typical High
$190.55
Cigna
Setting
Facility
Modifier
Global
Typical Low
$57.54
Median
$346.74
Typical High
$467.74
Cigna
Setting
Professional
Modifier
Global
Typical Low
$35.48
Median
$91.20
Typical High
$208.93
Medica
Setting
Facility
Modifier
Global
Typical Low
$141.25
Median
$229.09
Typical High
$912.01
Medica
Setting
Professional
Modifier
Global
Typical Low
$50.12
Median
$97.72
Typical High
$954.99
United
Setting
Facility
Modifier
Global
Typical Low
$69.18
Median
$190.55
Typical High
$229.09
United
Setting
Professional
Modifier
Global
Typical Low
$50.12
Median
$95.50
Typical High
$257.04

Where Missouri sits

The same service costs 6.9 times more in Alaska than in California. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Missouri $170 · 27th of 51
AK $437CA $63.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.