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SEPT9 Methylation Blood Test for Colon Cancer

New York rates for HCPCS 81327

A blood test that looks for a chemical change called methylation affecting the SEPT9 gene. This change is frequently present when colorectal cancer is developing, so finding it in blood flags the need for a closer look at the bowel. It is offered as a colorectal cancer screening option for people who will not undergo other forms of screening.

Rates data updated October 2026.

How much does SEPT9 Methylation Blood Test for Colon Cancer cost?

$151

Typical negotiated rate. In New York, October 2026.

Insurers have agreed to pay about $151 for this service. The price depends on where it is billed: about $145 from a physician practice, and about $316 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$145$81.28 to $219
FacilityA hospital or hospital-owned outpatient department$316$186 to $457

How much rates vary

Facilitymedian $316 · 10th to 90th $100 to $501Professionalmedian $145 · 10th to 90th $50 to $389
$20$50$100$200$500facility $316professional $145

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$45.71
Median
$151.36
Typical High
$588.84
Aetna
Setting
Professional
Modifier
None
Typical Low
$45.71
Median
$45.71
Typical High
$162.18
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$87.10
Median
$239.88
Typical High
$436.52
CDPHP
Setting
Professional
Modifier
None
Typical Low
$190.55
Median
$190.55
Typical High
$190.55
Cigna
Setting
Facility
Modifier
None
Typical Low
$186.21
Median
$407.38
Typical High
$501.19
Cigna
Setting
Professional
Modifier
None
Typical Low
$74.13
Median
$107.15
Typical High
$467.74
Emblem Health
Setting
Facility
Modifier
None
Typical Low
$190.55
Median
$316.23
Typical High
$524.81
Emblem Health
Setting
Professional
Modifier
None
Typical Low
$134.90
Median
$162.18
Typical High
$275.42
Excellus BCBS
Setting
Professional
Modifier
None
Typical Low
$123.03
Median
$190.55
Typical High
$218.78
MVP Health Care
Setting
Facility
Modifier
None
Typical Low
$13.80
Median
$257.04
Typical High
$380.19
MVP Health Care
Setting
Professional
Modifier
None
Typical Low
$63.10
Median
$95.50
Typical High
$398.11
United
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$190.55
Typical High
$239.88
United
Setting
Professional
Modifier
None
Typical Low
$75.86
Median
$87.10
Typical High
$288.40
Univera
Setting
Facility
Modifier
None
Typical Low
$97.72
Median
$123.03
Typical High
$204.17
Univera
Setting
Professional
Modifier
None
Typical Low
$114.82
Median
$190.55
Typical High
$218.78
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$22.91
Median
$22.91
Typical High
$81.28
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$9.12
Median
$9.12
Typical High
$32.36

Where New York sits

The same service costs 5.4 times more in Texas than in Ohio. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

New York· 27th of 51

$151

TX $468OH $87.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.