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SEPT9 Methylation Blood Test for Colon Cancer

Illinois rates for HCPCS 81327

A blood test that looks for a chemical change called methylation affecting the SEPT9 gene. This change is frequently present when colorectal cancer is developing, so finding it in blood flags the need for a closer look at the bowel. It is offered as a colorectal cancer screening option for people who will not undergo other forms of screening.

Rates data updated October 2026.

How much does SEPT9 Methylation Blood Test for Colon Cancer cost?

$148

Typical negotiated rate. In Illinois, October 2026.

Insurers have agreed to pay about $148 for this service. The price depends on where it is billed: about $135 from a physician practice, and about $372 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$135$50.12 to $158
FacilityA hospital or hospital-owned outpatient department$372$251 to $589

How much rates vary

Facilitymedian $372 · 10th to 90th $200 to $977Professionalmedian $135 · 10th to 90th $3 to $263
$5$20$100$500$2Kfacility $372professional $135

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$158.49
Median
$309.03
Typical High
$575.44
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$79.43
Median
$151.36
Typical High
$288.40
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$31.62
Median
$60.26
Typical High
$117.49
Aetna
Setting
Professional
Modifier
None
Typical Low
$70.79
Median
$158.49
Typical High
$165.96
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$77.62
Median
$79.43
Typical High
$87.10
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$30.90
Median
$31.62
Typical High
$34.67
BCBS Illinois
Setting
Facility
Modifier
None
Typical Low
$229.09
Median
$309.03
Typical High
$2,398.83
BCBS Illinois
Setting
Professional
Modifier
None
Typical Low
$3.47
Median
$131.83
Typical High
$147.91
Cigna
Setting
Facility
Modifier
None
Typical Low
$213.80
Median
$457.09
Typical High
$831.76
Cigna
Setting
Professional
Modifier
None
Typical Low
$38.90
Median
$117.49
Typical High
$281.84
Hally Health
Setting
Professional
Modifier
None
Typical Low
$190.55
Median
$269.15
Typical High
$389.05
Hally Health
Setting
Facility
Modifier
None
Typical Low
$100.00
Median
$100.00
Typical High
$100.00
Hally Health
Setting
Professional
Modifier
None
Typical Low
$251.19
Median
$251.19
Typical High
$251.19
United
Setting
Facility
Modifier
None
Typical Low
$190.55
Median
$229.09
Typical High
$239.88
United
Setting
Professional
Modifier
None
Typical Low
$45.71
Median
$87.10
Typical High
$165.96

Where Illinois sits

The same service costs 5.4 times more in Texas than in Ohio. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Illinois· 28th of 51

$148

TX $468OH $87.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.