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SEPT9 Methylation Blood Test for Colon Cancer

Virginia rates for HCPCS 81327

A blood test that looks for a chemical change called methylation affecting the SEPT9 gene. This change is frequently present when colorectal cancer is developing, so finding it in blood flags the need for a closer look at the bowel. It is offered as a colorectal cancer screening option for people who will not undergo other forms of screening.

Rates data updated October 2026.

How much does SEPT9 Methylation Blood Test for Colon Cancer cost?

$132

Typical negotiated rate. In Virginia, October 2026.

Insurers have agreed to pay about $132 for this service. The price depends on where it is billed: about $115 from a physician practice, and about $347 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$115$63.10 to $155
FacilityA hospital or hospital-owned outpatient department$347$195 to $776

How much rates vary

Facilitymedian $347 · 10th to 90th $107 to $1,122Professionalmedian $115 · 10th to 90th $35 to $229
$20$100$500$2K$10Kfacility $347professional $115

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$144.54
Median
$162.18
Typical High
$446.68
Aetna
Setting
Professional
Modifier
None
Typical Low
$144.54
Median
$144.54
Typical High
$162.18
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$724.44
Median
$933.25
Typical High
$1,174.90
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$33.11
Median
$47.86
Typical High
$131.83
CareFirst
Setting
Professional
Modifier
None
Typical Low
$138.04
Median
$154.88
Typical High
$181.97
Cigna
Setting
Facility
Modifier
None
Typical Low
$194.98
Median
$371.54
Typical High
$575.44
Cigna
Setting
Professional
Modifier
None
Typical Low
$39.81
Median
$107.15
Typical High
$190.55
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$181.97
Median
$208.93
Typical High
$269.15
Medcost
Setting
Facility
Modifier
None
Typical Low
$112.20
Median
$112.20
Typical High
$346.74
Medcost
Setting
Professional
Modifier
None
Typical Low
$83.18
Median
$83.18
Typical High
$95.50
Sentara
Setting
Facility
Modifier
None
Typical Low
$83.18
Median
$239.88
Typical High
$10,232.93
Sentara
Setting
Professional
Modifier
None
Typical Low
$83.18
Median
$177.83
Typical High
$851.14
United
Setting
Facility
Modifier
None
Typical Low
$229.09
Median
$229.09
Typical High
$229.09
United
Setting
Professional
Modifier
None
Typical Low
$35.48
Median
$87.10
Typical High
$162.18
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$72.44
Median
$72.44
Typical High
$81.28
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$28.84
Median
$28.84
Typical High
$32.36

Where Virginia sits

The same service costs 5.4 times more in Texas than in Ohio. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Virginia· 33rd of 51

$132

TX $468OH $87.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.