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SEPT9 Methylation Blood Test for Colon Cancer

Massachusetts rates for HCPCS 81327

A blood test that looks for a chemical change called methylation affecting the SEPT9 gene. This change is frequently present when colorectal cancer is developing, so finding it in blood flags the need for a closer look at the bowel. It is offered as a colorectal cancer screening option for people who will not undergo other forms of screening.

Rates data updated October 2026.

How much does SEPT9 Methylation Blood Test for Colon Cancer cost?

$191

Typical negotiated rate. In Massachusetts, October 2026.

Insurers have agreed to pay about $191 for this service. The price depends on where it is billed: about $191 from a physician practice, and about $263 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$191$87.10 to $490
FacilityA hospital or hospital-owned outpatient department$263$195 to $347

How much rates vary

Facilitymedian $263 · 10th to 90th $151 to $589Professionalmedian $191 · 10th to 90th $59 to $955
$100$200$500$1K$2K$5Kfacility $263professional $191

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$58.88
Median
$117.49
Typical High
$263.03
Aetna
Setting
Professional
Modifier
None
Typical Low
$58.88
Median
$58.88
Typical High
$58.88
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$194.98
Median
$263.03
Typical High
$630.96
AllWays Health Partners
Setting
Professional
Modifier
None
Typical Low
$81.28
Median
$363.08
Typical High
$954.99
BCBS Massachusetts
Setting
Facility
Modifier
None
Typical Low
$190.55
Median
$269.15
Typical High
$389.05
BCBS Massachusetts
Setting
Professional
Modifier
None
Typical Low
$45.71
Median
$45.71
Typical High
$45.71
Cigna
Setting
Facility
Modifier
None
Typical Low
$54.95
Median
$114.82
Typical High
$338.84
Cigna
Setting
Professional
Modifier
None
Typical Low
$102.33
Median
$173.78
Typical High
$741.31
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$83.18
Median
$323.59
Typical High
$5,888.44
Fallon Health
Setting
Professional
Modifier
None
Typical Low
$275.42
Median
$275.42
Typical High
$323.59
Harvard Pilgrim
Setting
Professional
Modifier
None
Typical Low
$77.62
Median
$190.55
Typical High
$457.09
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$194.98
Median
$263.03
Typical High
$630.96
Mass General Brigham
Setting
Professional
Modifier
None
Typical Low
$81.28
Median
$363.08
Typical High
$954.99
United
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$190.55
Typical High
$229.09
United
Setting
Professional
Modifier
None
Typical Low
$50.12
Median
$114.82
Typical High
$363.08
Well Sense
Setting
Facility
Modifier
None
Typical Low
$169.82
Median
$234.42
Typical High
$346.74
Well Sense
Setting
Professional
Modifier
None
Typical Low
$63.10
Median
$63.10
Typical High
$74.13
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$29.51
Median
$29.51
Typical High
$29.51
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$11.75
Median
$11.75
Typical High
$11.75
Fallon Health
Setting
Facility
Modifier
QW · Waived lab test
Typical Low
$190.55
Median
$251.19
Typical High
$295.12

Where Massachusetts sits

The same service costs 5.4 times more in Texas than in Ohio. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 16th of 51

$191

TX $468OH $87.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.