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SEPT9 Methylation Blood Test for Colon Cancer

Massachusetts rates for HCPCS 81327

A blood test that looks for a chemical change called methylation affecting the SEPT9 gene. This change is frequently present when colorectal cancer is developing, so finding it in blood flags the need for a closer look at the bowel. It is offered as a colorectal cancer screening option for people who will not undergo other forms of screening.

Rates data updated July 2026.

How much does SEPT9 Methylation Blood Test for Colon Cancer cost?

$191

Typical negotiated rate. In Massachusetts, July 2026.

Insurers have agreed to pay about $191 for this service. The price depends on where it is billed: about $191 from a physician practice, and about $263 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$191$115 to $191
FacilityA hospital or hospital-owned outpatient department$263$191 to $389

How much rates vary

Facilitymedian $263 · 10th to 90th $117 to $562Professionalmedian $191 · 10th to 90th $59 to $479
$100.0$1.0K$10.0Kfacility $263professional $191

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$58.88
Median
$275.42
Typical High
$562.34
Aetna
Setting
Professional
Modifier
Global
Typical Low
$45.71
Median
$61.66
Typical High
$575.44
AllWays Health Partners
Setting
Facility
Modifier
Global
Typical Low
$194.98
Median
$537.03
Typical High
$912.01
AllWays Health Partners
Setting
Professional
Modifier
Global
Typical Low
$81.28
Median
$169.82
Typical High
$562.34
BCBS
Setting
Facility
Modifier
Global
Typical Low
$190.55
Median
$239.88
Typical High
$346.74
BCBS
Setting
Professional
Modifier
Global
Typical Low
$45.71
Median
$45.71
Typical High
$45.71
Cigna
Setting
Facility
Modifier
Global
Typical Low
$54.95
Median
$114.82
Typical High
$309.03
Cigna
Setting
Professional
Modifier
Global
Typical Low
$48.98
Median
$151.36
Typical High
$371.54
Fallon Health
Setting
Facility
Modifier
Global
Typical Low
$56.23
Median
$478.63
Typical High
$7,079.46
Fallon Health
Setting
Professional
Modifier
Global
Typical Low
$144.54
Median
$275.42
Typical High
$323.59
Harvard Pilgrim
Setting
Professional
Modifier
Global
Typical Low
$190.55
Median
$190.55
Typical High
$346.74
Mass General Brigham
Setting
Facility
Modifier
Global
Typical Low
$194.98
Median
$537.03
Typical High
$912.01
Mass General Brigham
Setting
Professional
Modifier
Global
Typical Low
$81.28
Median
$169.82
Typical High
$562.34
United
Setting
Facility
Modifier
Global
Typical Low
$75.86
Median
$173.78
Typical High
$218.78
United
Setting
Professional
Modifier
Global
Typical Low
$77.62
Median
$190.55
Typical High
$426.58

Where Massachusetts sits

The same service costs 6.9 times more in Alaska than in California. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Massachusetts $191 · 18th of 51
AK $437CA $63.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.