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SEPT9 Methylation Blood Test for Colon Cancer

Alabama rates for HCPCS 81327

A blood test that looks for a chemical change called methylation affecting the SEPT9 gene. This change is frequently present when colorectal cancer is developing, so finding it in blood flags the need for a closer look at the bowel. It is offered as a colorectal cancer screening option for people who will not undergo other forms of screening.

Rates data updated October 2026.

How much does SEPT9 Methylation Blood Test for Colon Cancer cost?

$174

Typical negotiated rate. In Alabama, October 2026.

Insurers have agreed to pay about $174 for this service. The price depends on where it is billed: about $95.50 from a physician practice, and about $174 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 4 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$95.50$50.12 to $219
FacilityA hospital or hospital-owned outpatient department$174$174 to $174

How much rates vary

Facilitymedian $174 · 10th to 90th $174 to $174Professionalmedian $95 · 10th to 90th $42 to $219
$50$100$200$500facility $174professional $95

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$218.78
Median
$218.78
Typical High
$295.12
Aetna
Setting
Professional
Modifier
None
Typical Low
$128.82
Median
$218.78
Typical High
$218.78
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$74.13
Median
$109.65
Typical High
$109.65
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$30.20
Median
$44.67
Typical High
$44.67
BCBS Alabama
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$173.78
Typical High
$173.78
BCBS Alabama
Setting
Professional
Modifier
21 + 22 · Increased work + 24 · Unrelated visit after surgery + 31
Typical Low
$42.66
Median
$61.66
Typical High
$61.66
Cigna
Setting
Facility
Modifier
None
Typical Low
$125.89
Median
$154.88
Typical High
$616.60
Cigna
Setting
Professional
Modifier
None
Typical Low
$31.62
Median
$43.65
Typical High
$104.71
United
Setting
Facility
Modifier
None
Typical Low
$69.18
Median
$173.78
Typical High
$190.55
United
Setting
Professional
Modifier
None
Typical Low
$45.71
Median
$81.28
Typical High
$114.82

Where Alabama sits

The same service costs 5.4 times more in Texas than in Ohio. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Alabama· 21st of 51

$174

TX $468OH $87.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.