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SEPT9 Methylation Blood Test for Colon Cancer

Maryland rates for HCPCS 81327

A blood test that looks for a chemical change called methylation affecting the SEPT9 gene. This change is frequently present when colorectal cancer is developing, so finding it in blood flags the need for a closer look at the bowel. It is offered as a colorectal cancer screening option for people who will not undergo other forms of screening.

Rates data updated October 2026.

How much does SEPT9 Methylation Blood Test for Colon Cancer cost?

$141

Typical negotiated rate. In Maryland, October 2026.

Insurers have agreed to pay about $141 for this service. Most negotiated rates run $115 to $155.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $141 · 10th to 90th $81 to $191
$50$100$200$500professional $141

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
None
Typical Low
$141.25
Median
$144.54
Typical High
$158.49
CareFirst
Setting
Professional
Modifier
None
Typical Low
$138.04
Median
$154.88
Typical High
$154.88
Cigna
Setting
Professional
Modifier
None
Typical Low
$45.71
Median
$125.89
Typical High
$549.54
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$181.97
Median
$229.09
Typical High
$288.40
United
Setting
Professional
Modifier
None
Typical Low
$35.48
Median
$87.10
Typical High
$162.18
Wellpoint
Setting
Professional
Modifier
None
Typical Low
$95.50
Median
$95.50
Typical High
$154.88
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$70.79
Median
$72.44
Typical High
$79.43
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$28.18
Median
$28.84
Typical High
$31.62

Where Maryland sits

The same service costs 5.4 times more in Texas than in Ohio. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Maryland· 30th of 51

$141

TX $468OH $87.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.